Universität zu Köln

Manthou, Maria Eleni, Gencheva, Dilyana, Sinis, Nektarios, Rink, Svenja, Papamitsou, Theodora ORCID: 0000-0002-0709-5407, Abdulla, Diana, Bendella, Habib, Sarikcioglu, Levent and Angelov, Doychin N. . Facial Nerve Repair by Muscle-Vein Conduit in Rats: Functional Recovery and Muscle Reinnervation. Tissue Eng. Part A. NEW ROCHELLE: MARY ANN LIEBERT, INC. ISSN 1937-335X

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Abstract

The facial nerve is the most frequently damaged nerve in head and neck traumata. Repair of interrupted nerves is generally reinforced by fine microsurgical techniques; nevertheless, regaining all functions is the exception rather than the rule. The so-called postparalytic syndrome, which includes synkinesia and altered blink reflexes, follows nerve injury. The purpose of this study was to examine if nerve-gap repair using an autologous vein filled with skeletal muscle would improve axonal regeneration, reduce neuromuscular junction polyinnervation, and improve the recovery of whisking in rats with transected and sutured right buccal branches of the facial nerve. Vibrissal motor performance was studied with the use of a video motion analysis. Immunofluorescence was used to visualize and analyze target muscle reinnervation. The results taken together indicate a positive effect of muscle-vein-combined conduit (MVCC) on the improvement of the whisking function after reparation of the facial nerve in rats. The findings support the recent suggestion that a venal graft with implantation of a trophic source, such as autologous denervated skeletal muscle, may promote the monoinnervation degree and ameliorate coordinated function of the corresponding muscles. Impact statement This is the first attempt for facial nerve repair with muscle-vein-combined conduit. The findings indicate that a venal graft with implantation of a trophic source, such as autologous denervated skeletal muscle, may promote the monoinnervation degree and improve coordinated activity of the corresponding muscles.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Manthou, Maria Eleni UNSPECIFIED UNSPECIFIED UNSPECIFIED Gencheva, Dilyana UNSPECIFIED UNSPECIFIED UNSPECIFIED Sinis, Nektarios UNSPECIFIED UNSPECIFIED UNSPECIFIED Rink, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Papamitsou, Theodora UNSPECIFIED orcid.org/0000-0002-0709-5407 UNSPECIFIED Abdulla, Diana UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarikcioglu, Levent UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-312160
DOI:	10.1089/ten.tea.2020.0045
Journal or Publication Title:	Tissue Eng. Part A
Publisher:	MARY ANN LIEBERT, INC
Place of Publication:	NEW ROCHELLE
ISSN:	1937-335X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SCIATIC-NERVE; SKELETAL-MUSCLE; AUTOGENOUS VEIN; SELECTIVE REINNERVATION; NEUROTROPHIC FACTOR; MANUAL STIMULATION; VIBRISSAL MOVEMENT; ORBICULARIS OCULI; PERIPHERAL-NERVES; SCHWANN-CELLS Multiple languages Cell & Tissue Engineering; Cell Biology; Engineering, Biomedical; Materials Science, Biomaterials Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31216