Universität zu Köln

Schmutzler, Rita (2020). Risk-adjusted prevention of hereditary breast and ovarian cancer: conceptual framework and implementation. Gynakologe, 53 (11). S. 734 - 739. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0393

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Abstract

The increasing knowledge about risk factors and especially high-risk genes has brought risk-adapted cancer prevention into the focus as a potentially more effective prevention concept than conventional prevention strategies that are geared to the population as a whole; however, carrying out prospective randomized studies to provide evidence for risk-adapted prevention measures is problematic, since the evidence of a significantly increased risk is associated with a low acceptance by those affected with respect to randomization. This is aggravated by the fact that genetically defined subgroups are often too small to perform randomized controlled trials (RCT) usually within a limited time frame. In this situation framework concepts have been developed that enable a structured and systematic generation of evidence. The German Consortium of Familial Breast and Ovarian Cancer has taken up these concepts and integrated them into a care concept that enables knowledge generation and at the same time nationwide networked care.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-312205
DOI:	10.1007/s00129-020-04684-2
Journal or Publication Title:	Gynakologe
Volume:	53
Number:	11
Page Range:	S. 734 - 739
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0393
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31220