Universität zu Köln

Tscherpel, Caroline and Grefkes, Christian . Functional Recovery after Stroke and the Therapeutic Relevance of Non-invasive Brain Stimulation. Klin. Neurophysiol.. STUTTGART: GEORG THIEME VERLAG KG. ISSN 1439-4081

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Abstract

Zusammenfassung Im Bereich der non-invasiven Hirnstimulation stellen die transkranielle Magnetstimulation (engl. transcranial magnetic stimulation, TMS) sowie die transkranielle Gleichstromstimulation (engl. transcranial direct current stimulation, tDCS) bis heute die wichtigsten Techniken zur Modulation kortikaler Erregbarkeit dar. Beide Verfahren induzieren Nacheffekte, welche die Zeit der reinen Stimulation uberdauern, und ebnen damit den Weg fur ihren therapeutischen Einsatz beim Schlaganfall. In diesem ubersichtsartikel diskutieren wir die aktuelle Datenlage TMS- und tDCS-vermittelter Therapien fur die haufigsten schlaganfallbedingten Defizite wie Hemiparese, Aphasie und Neglect. Daruber hinaus adressieren wir mogliche Einschrankungen der gegenwartigen Ansatze und zeigen Ansatzpunkte auf, um Neuromodulation nach Schlaganfall effektiver zu gestalten und damit das Outcome der Patienten zu verbessern. Abstract Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) currently represent the most important techniques for modulating cortical excitability. Both approaches induce after-effects that outlast the time of stimulation, and thus form the foundation for their therapeutic use in stroke rehabilitation. The purpose of this review is to discuss current data on non-invasive stimulation therapies for the most common stroke-related deficits, i.e., hemiparesis, aphasia and neglect. In addition, we address current limitations and finally suggest strategies to potentially increase the effectiveness of neuromodulation after stroke in order to improve patients' outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tscherpel, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED Grefkes, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314101
DOI:	10.1055/a-1272-9435
Journal or Publication Title:	Klin. Neurophysiol.
Publisher:	GEORG THIEME VERLAG KG
Place of Publication:	STUTTGART
ISSN:	1439-4081
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language TRANSCRANIAL MAGNETIC STIMULATION; THETA-BURST STIMULATION; MOTOR CORTEX EXCITABILITY; SHAM-CONTROLLED TRIAL; CORTICAL EXCITABILITY; NONFLUENT APHASIA; PARIETAL CORTEX; LEFT-HEMISPHERE; NEURAL REPAIR; DOUBLE-BLIND Multiple languages Clinical Neurology; Neuroimaging; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31410