Universität zu Köln

Wang, Zhefang, Liu, Fanyu, Fan, Ningbo, Zhou, Chenghui, Li, Dai, Macvicar, Thomas, Dong, Qiongzhu, Bruns, Christiane J. and Zhao, Yue (2020). Targeting Glutaminolysis: New Perspectives to Understand Cancer Development and Novel Strategies for Potential Target Therapies. Front. Oncol., 10. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2234-943X

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Abstract

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis, tumor growth, and the production of antioxidants through glutaminolysis in cancers. In glutamine dependent cancer cells, more than half of the tricarboxylic/critic acid (TCA) metabolites are derived from glutamine. Glutaminolysis controls the process of converting glutamine into TCA cycle metabolites through the regulation of multiple enzymes, among which the glutaminase shows the importance as the very first step in this process. Targeting glutaminolysis via glutaminase inhibition emerges as a promising strategy to disrupt cancer metabolism and tumor progression. Here, we review the regulation of glutaminase and the role of glutaminase in cancer metabolism and metastasis. Furthermore, we highlight the glutaminase inhibitor based metabolic therapy strategy and their potential applications in clinical scenarios.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Zhefang UNSPECIFIED UNSPECIFIED UNSPECIFIED Liu, Fanyu UNSPECIFIED UNSPECIFIED UNSPECIFIED Fan, Ningbo UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhou, Chenghui UNSPECIFIED UNSPECIFIED UNSPECIFIED Li, Dai UNSPECIFIED UNSPECIFIED UNSPECIFIED Macvicar, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Dong, Qiongzhu UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314318
DOI:	10.3389/fonc.2020.589508
Journal or Publication Title:	Front. Oncol.
Volume:	10
Date:	2020
Publisher:	FRONTIERS MEDIA SA
Place of Publication:	LAUSANNE
ISSN:	2234-943X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language KIDNEY-TYPE GLUTAMINASE; REDUCTIVE CARBOXYLATION; OXIDATIVE STRESS; TUMOR-GROWTH; METABOLISM; CELL; EXPRESSION; PROLIFERATION; GLUCOSE; GLS2 Multiple languages Oncology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31431