Universität zu Köln

Kast, Karin, Rhiem, Kerstin and Schmutzler, Rita (2020). Hereditary breast and ovarian cancer (and hormones). Gynakologe, 53 (11). S. 739 - 748. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1433-0393

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Abstract

Knowledge of carriership of a predisposition for hereditary breast and ovarian cancer (HBOC) imposes greater demands on gynaecologists, patients and healthy mutation carriers in terms of prevention, therapy and aftercare. Treatment with poly ADP ribose polymerase (PARP) inhibitors is still mainly reserved for tumors with positive breast cancer gene (BRCA) status. The results of healthcare research has enabled a differentiated discussion of the significance of intensified surveillance of the breast compared to risk-reducing surgery in the face of competing risks. Although the clinical care of carriers of a pathogenic variant of BRCA1 or BRCA2 has been introduced in the clinical guidelines, many questions remain unanswered, such as the influence of exogenous hormones and other genetic and non-genetic risk factors on cancer risk. In addition, the characteristics of the newer HBOC genes with moderate risk for breast and/or ovarian cancer and of the rare syndromic genes are not well known as yet. The following article presents HBOC syndrome with current clinical recommendations, including hormonal contraception.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kast, Karin UNSPECIFIED UNSPECIFIED UNSPECIFIED Rhiem, Kerstin UNSPECIFIED UNSPECIFIED UNSPECIFIED Schmutzler, Rita UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314503
DOI:	10.1007/s00129-020-04697-x
Journal or Publication Title:	Gynakologe
Volume:	53
Number:	11
Page Range:	S. 739 - 748
Date:	2020
Publisher:	SPRINGER HEIDELBERG
Place of Publication:	HEIDELBERG
ISSN:	1433-0393
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language BRCA2 MUTATION CARRIERS; LI-FRAUMENI SYNDROME; RISK; MAINTENANCE; CONSORTIUM; OLAPARIB Multiple languages Obstetrics & Gynecology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31450