Universität zu Köln

Sujana, Chaterina, Seissler, Jochen, Jordan, Jens, Rathmann, Wolfgang, Koenig, Wolfgang, Roden, Michael, Mansmann, Ulrich, Herder, Christian, Peters, Annette ORCID: 0000-0001-6645-0985, Thorand, Barbara ORCID: 0000-0002-8416-6440 and Then, Cornelia (2020). Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study. Cardiovasc. Diabetol., 19 (1). LONDON: BMC. ISSN 1475-2840

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Abstract

Background High N-terminal pro-brain-type natriuretic peptide levels have been associated with a lower risk of type 2 diabetes mellitus (T2D). However, less is known about other cardiac stress biomarkers in this context. Here we evaluated the association of mid-regional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine vasopressin (copeptin), C-terminal pro-endothelin-1 (CT-proET-1) and mid-regional pro-adrenomedullin (MR-proADM) with incident T2D and changes in glucose metabolism. Methods We performed a prospective cohort study using data from the population-based KORA F4/FF4 study. 1773 participants (52.3% women) with MR-proANP measurements and 960 (52.7% women) with copeptin, CT-proET-1 and MR-proADM measurements were included. We examined associations of circulating plasma levels of MR-proANP, copeptin, CT-proET-1 and MR-proADM with incident T2D, the combined endpoint of incident prediabetes/T2D and with fasting and 2 h-glucose, fasting insulin, HOMA-IR, HOMA-B and HbA1c at follow-up. Logistic and linear regression models adjusted for age, sex, waist circumference, height, hypertension, total/HDL cholesterol ratio, triglycerides, smoking, physical activity and parental history of diabetes were used to compute effect estimates. Results During a median follow-up time of 6.4 years (25th and 75th percentiles: 6.0 and 6.6, respectively), 119 out of the 1773 participants and 72 out of the 960 participants developed T2D. MR-proANP was inversely associated with incident T2D (odds ratio [95% confidence interval]: 0.75 [0.58; 0.96] per 1-SD increase of log MR-proANP). Copeptin was positively associated with incident prediabetes/T2D (1.29 [1.02; 1.63] per 1-SD increase of log copeptin). Elevated levels of CT-proET-1 were associated with increased HOMA-B at follow-up, while elevated MR-proADM levels were associated with increased fasting insulin, HOMA-IR and HOMA-B at follow-up. These associations were independent of previously described diabetes risk factors. Conclusions High plasma concentrations of MR-proANP contributed to a lower risk of incident T2D, whereas high plasma concentrations of copeptin were associated with an increased risk of incident prediabetes/T2D. Furthermore, high plasma concentrations of CT-proET-1 and MR-proADM were associated with increased insulin resistance. Our study provides evidence that biomarkers implicated in cardiac stress are associated with incident T2D and changes in glucose metabolism.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sujana, Chaterina UNSPECIFIED UNSPECIFIED UNSPECIFIED Seissler, Jochen UNSPECIFIED UNSPECIFIED UNSPECIFIED Jordan, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Rathmann, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Koenig, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Roden, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Mansmann, Ulrich UNSPECIFIED UNSPECIFIED UNSPECIFIED Herder, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Annette UNSPECIFIED orcid.org/0000-0001-6645-0985 UNSPECIFIED Thorand, Barbara UNSPECIFIED orcid.org/0000-0002-8416-6440 UNSPECIFIED Then, Cornelia UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-314763
DOI:	10.1186/s12933-020-01117-1
Journal or Publication Title:	Cardiovasc. Diabetol.
Volume:	19
Number:	1
Date:	2020
Publisher:	BMC
Place of Publication:	LONDON
ISSN:	1475-2840
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATRIAL-NATRIURETIC-PEPTIDE; INSULIN-RESISTANCE; PLASMA COPEPTIN; HEART-FAILURE; ADRENOMEDULLIN; RISK; SECRETION; INFLAMMATION; PREVALENCE; MELLITUS Multiple languages Cardiac & Cardiovascular Systems; Endocrinology & Metabolism Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31476