Sujana, Chaterina, Seissler, Jochen, Jordan, Jens, Rathmann, Wolfgang, Koenig, Wolfgang, Roden, Michael, Mansmann, Ulrich, Herder, Christian, Peters, Annette ORCID: 0000-0001-6645-0985, Thorand, Barbara ORCID: 0000-0002-8416-6440 and Then, Cornelia (2020). Associations of cardiac stress biomarkers with incident type 2 diabetes and changes in glucose metabolism: KORA F4/FF4 study. Cardiovasc. Diabetol., 19 (1). LONDON: BMC. ISSN 1475-2840

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Abstract

Background High N-terminal pro-brain-type natriuretic peptide levels have been associated with a lower risk of type 2 diabetes mellitus (T2D). However, less is known about other cardiac stress biomarkers in this context. Here we evaluated the association of mid-regional pro-atrial natriuretic peptide (MR-proANP), C-terminal pro-arginine vasopressin (copeptin), C-terminal pro-endothelin-1 (CT-proET-1) and mid-regional pro-adrenomedullin (MR-proADM) with incident T2D and changes in glucose metabolism. Methods We performed a prospective cohort study using data from the population-based KORA F4/FF4 study. 1773 participants (52.3% women) with MR-proANP measurements and 960 (52.7% women) with copeptin, CT-proET-1 and MR-proADM measurements were included. We examined associations of circulating plasma levels of MR-proANP, copeptin, CT-proET-1 and MR-proADM with incident T2D, the combined endpoint of incident prediabetes/T2D and with fasting and 2 h-glucose, fasting insulin, HOMA-IR, HOMA-B and HbA1c at follow-up. Logistic and linear regression models adjusted for age, sex, waist circumference, height, hypertension, total/HDL cholesterol ratio, triglycerides, smoking, physical activity and parental history of diabetes were used to compute effect estimates. Results During a median follow-up time of 6.4 years (25th and 75th percentiles: 6.0 and 6.6, respectively), 119 out of the 1773 participants and 72 out of the 960 participants developed T2D. MR-proANP was inversely associated with incident T2D (odds ratio [95% confidence interval]: 0.75 [0.58; 0.96] per 1-SD increase of log MR-proANP). Copeptin was positively associated with incident prediabetes/T2D (1.29 [1.02; 1.63] per 1-SD increase of log copeptin). Elevated levels of CT-proET-1 were associated with increased HOMA-B at follow-up, while elevated MR-proADM levels were associated with increased fasting insulin, HOMA-IR and HOMA-B at follow-up. These associations were independent of previously described diabetes risk factors. Conclusions High plasma concentrations of MR-proANP contributed to a lower risk of incident T2D, whereas high plasma concentrations of copeptin were associated with an increased risk of incident prediabetes/T2D. Furthermore, high plasma concentrations of CT-proET-1 and MR-proADM were associated with increased insulin resistance. Our study provides evidence that biomarkers implicated in cardiac stress are associated with incident T2D and changes in glucose metabolism.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Sujana, ChaterinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seissler, JochenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Jordan, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rathmann, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Koenig, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roden, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mansmann, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Herder, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, AnnetteUNSPECIFIEDorcid.org/0000-0001-6645-0985UNSPECIFIED
Thorand, BarbaraUNSPECIFIEDorcid.org/0000-0002-8416-6440UNSPECIFIED
Then, CorneliaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-314763
DOI: 10.1186/s12933-020-01117-1
Journal or Publication Title: Cardiovasc. Diabetol.
Volume: 19
Number: 1
Date: 2020
Publisher: BMC
Place of Publication: LONDON
ISSN: 1475-2840
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ATRIAL-NATRIURETIC-PEPTIDE; INSULIN-RESISTANCE; PLASMA COPEPTIN; HEART-FAILURE; ADRENOMEDULLIN; RISK; SECRETION; INFLAMMATION; PREVALENCE; MELLITUSMultiple languages
Cardiac & Cardiovascular Systems; Endocrinology & MetabolismMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31476

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