Universität zu Köln

Bayer, Emily A., Stecky, Rebecca C., Neal, Lauren, Katsamba, Phinikoula S., Ahlsen, Goran, Balaji, Vishnu, Hoppe, Thorsten ORCID: 0000-0002-4734-9352, Shapiro, Lawrence, Oren-Suissa, Meital and Hobert, Oliver ORCID: 0000-0002-7634-2854 (2020). Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explored feature of animal brains. We describe here a novel mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the nervous system of the nematode Caenorhabditis elegans. We demonstrate that a phylogenetically conserved, but previously uncharacterized Doublesex/Mab-3 related transcription factor (DMRT), dmd-4, is expressed in two classes of sex-shared phasmid neurons specifically in hermaphrodites but not in males. We find dmd-4 to promote hermaphrodite-specific synaptic connectivity and neuronal function of phasmid sensory neurons. Sex-specificity of DMD-4 function is conferred by a novel mode of posttranslational regulation that involves sex-specific protein stabilization through ubiquitin binding to a phylogenetically conserved but previously unstudied protein domain, the DMA domain. A human DMRT homolog of DMD-4 is controlled in a similar manner, indicating that our findings may have implications for the control of sexual differentiation in other animals as well.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Bayer, Emily A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Stecky, Rebecca C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Neal, Lauren UNSPECIFIED UNSPECIFIED UNSPECIFIED Katsamba, Phinikoula S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ahlsen, Goran UNSPECIFIED UNSPECIFIED UNSPECIFIED Balaji, Vishnu UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppe, Thorsten UNSPECIFIED orcid.org/0000-0002-4734-9352 UNSPECIFIED Shapiro, Lawrence UNSPECIFIED UNSPECIFIED UNSPECIFIED Oren-Suissa, Meital UNSPECIFIED UNSPECIFIED UNSPECIFIED Hobert, Oliver UNSPECIFIED orcid.org/0000-0002-7634-2854 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-315613
DOI:	10.7554/eLife.59614
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language C-ELEGANS; CUE DOMAIN; GENE FAMILY; SEX; CELL; NEMATODE; DIFFERENTIATION; DOUBLESEX; NEURONS; BINDING Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/31561