Bayer, Emily A., Stecky, Rebecca C., Neal, Lauren, Katsamba, Phinikoula S., Ahlsen, Goran, Balaji, Vishnu, Hoppe, Thorsten, Shapiro, Lawrence, Oren-Suissa, Meital and Hobert, Oliver ORCID: 0000-0002-7634-2854 (2020). Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explored feature of animal brains. We describe here a novel mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the nervous system of the nematode Caenorhabditis elegans. We demonstrate that a phylogenetically conserved, but previously uncharacterized Doublesex/Mab-3 related transcription factor (DMRT), dmd-4, is expressed in two classes of sex-shared phasmid neurons specifically in hermaphrodites but not in males. We find dmd-4 to promote hermaphrodite-specific synaptic connectivity and neuronal function of phasmid sensory neurons. Sex-specificity of DMD-4 function is conferred by a novel mode of posttranslational regulation that involves sex-specific protein stabilization through ubiquitin binding to a phylogenetically conserved but previously unstudied protein domain, the DMA domain. A human DMRT homolog of DMD-4 is controlled in a similar manner, indicating that our findings may have implications for the control of sexual differentiation in other animals as well.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Bayer, Emily A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Stecky, Rebecca C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neal, LaurenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Katsamba, Phinikoula S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ahlsen, GoranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Balaji, VishnuUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoppe, ThorstenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shapiro, LawrenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oren-Suissa, MeitalUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hobert, OliverUNSPECIFIEDorcid.org/0000-0002-7634-2854UNSPECIFIED
URN: urn:nbn:de:hbz:38-315613
DOI: 10.7554/eLife.59614
Journal or Publication Title: eLife
Volume: 9
Date: 2020
Publisher: ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication: CAMBRIDGE
ISSN: 2050-084X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
C-ELEGANS; CUE DOMAIN; GENE FAMILY; SEX; CELL; NEMATODE; DIFFERENTIATION; DOUBLESEX; NEURONS; BINDINGMultiple languages
BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31561

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