Xanthopoulou, Kyriaki ORCID: 0000-0001-8591-8184, Peter, Silke ORCID: 0000-0002-1355-3953, Tobys, David, Behnke, Michael, Dinkelacker, Ariane G., Eisenbeis, Simone, Falgenhauer, Jane, Falgenhauer, Linda ORCID: 0000-0003-4706-8507, Fritzenwanker, Moritz, Goelz, Hannah, Haecker, Georg, Higgins, Paul G. ORCID: 0000-0001-8677-9454, Imirzalioglu, Can, Kaeding, Nadja, Kern, Winfried, V, Kramme, Evelyn, Kola, Axel, Mischnik, Alexander, Rieg, Siegbert, Rohde, Anna M., Rupp, Jan, Tacconelli, Evelina, Vehreschild, Maria J. G. T., Walker, Sarah, V, Gastmeier, Petra and Seifert, Harald (2020). Vancomycin-resistant Enterococcus faecium colonizing patients on hospital admission in Germany: prevalence and molecular epidemiology. J. Antimicrob. Chemother., 75 (10). S. 2743 - 2752. OXFORD: OXFORD UNIV PRESS. ISSN 1460-2091

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Abstract

Objectives: To analyse the rectal carriage rate and the molecular epidemiology of vancomycin-resistant Enterococcus faecium (VREfm) recovered from patients upon hospital admission. Methods: Adult patients were screened at six German university hospitals from five different federal states upon hospital admission for rectal colonization with VREfm between 2014 and 2018. Molecular characterization of VREfm was performed by WGS followed by MLST and core-genome MLST analysis. Results: Of 16350 patients recruited, 263 were colonized with VREfm, with increasing prevalence rates during the 5year study period (from 0.8% to 2.6%). In total, 78.5% of the VREfm were vanB positive and 20.2% vanA positive, while 1.2% harboured both vanA and vanB. The predominant ST was ST117 (56.7%) followed by ST80 (15%), ST203 (10.9%), ST78 (5.7%) and ST17 (3.2%). ST117/vanB VREfm isolates formed a large cluster of 96 closely related isolates extending across all six study centres and four smaller clusters comprising 13, 5, 4 and 3 isolates each. In contrast, among the other STs inter-regional clonal relatedness was rarely observed. Conclusions: To our knowledge, this is the largest admission prevalence and molecular epidemiology study of VREfm. These data provide insight into the epidemiology of VREfm at six German university hospitals and demonstrate the remarkable inter-regional clonal expansion of the ST117/vanB VREfm clone.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Xanthopoulou, KyriakiUNSPECIFIEDorcid.org/0000-0001-8591-8184UNSPECIFIED
Peter, SilkeUNSPECIFIEDorcid.org/0000-0002-1355-3953UNSPECIFIED
Tobys, DavidUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Behnke, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dinkelacker, Ariane G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eisenbeis, SimoneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falgenhauer, JaneUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Falgenhauer, LindaUNSPECIFIEDorcid.org/0000-0003-4706-8507UNSPECIFIED
Fritzenwanker, MoritzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Goelz, HannahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Haecker, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higgins, Paul G.UNSPECIFIEDorcid.org/0000-0001-8677-9454UNSPECIFIED
Imirzalioglu, CanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaeding, NadjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kern, Winfried, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kramme, EvelynUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kola, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mischnik, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rieg, SiegbertUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rohde, Anna M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rupp, JanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tacconelli, EvelinaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vehreschild, Maria J. G. T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Walker, Sarah, VUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gastmeier, PetraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Seifert, HaraldUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-315995
DOI: 10.1093/jac/dkaa271
Journal or Publication Title: J. Antimicrob. Chemother.
Volume: 75
Number: 10
Page Range: S. 2743 - 2752
Date: 2020
Publisher: OXFORD UNIV PRESS
Place of Publication: OXFORD
ISSN: 1460-2091
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MECHANISMS; OUTBREAKSMultiple languages
Infectious Diseases; Microbiology; Pharmacology & PharmacyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31599

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