Universität zu Köln

Harwoko, Harwoko ORCID: 0000-0002-4111-7147, Lee, Jungho, Hartmann, Rudolf, Mandi, Attila, Kurtan, Tibor, Mueller, Werner E. G., Feldbruegge, Michael, Kalscheuer, Rainer, Ancheeva, Elena, Daletos, Georgios, Frank, Marian ORCID: 0000-0003-3190-9076, Liu, Zhen and Proksch, Peter (2020). Azacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079. Fitoterapia, 146. AMSTERDAM: ELSEVIER. ISSN 1873-6971

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Abstract

Three new flavipin-derived alkaloids, azacoccones F-H (1-3), along with six known compounds (4-9) were isolated from the endophytic fungus Epicoccum nigrum MK214079 associated with leaves of Salix sp. The structures of the new compounds were established by analysis of their 1D/2D nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectroscopy (HRESIMS) data. The absolute configuration of azacoccones F-H (1-3) was determined by comparison of experimental electronic circular dichroism (ECD) data with reported ones and biogenetic considerations. Epicocconigrone A (4), epipyrone A (5), and epicoccolide B (6) exhibited moderate antibacterial activity against Staphylococcus aureus ATCC 29213 with minimal inhibitory concentration (MIC) values ranging from 25 to 50 mu M. Furthermore, epipyrone A (5) and epicoccamide A (7) displayed mild antifungal activity against Ustilago maydis AB33 with MIC values of 1.6 and 1.8 mM, respectively. Epicorazine A (8) showed pronounced cytotoxicity against the L5178Y mouse lymphoma cell line with an IC50 value of 1.3 mu M.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Harwoko, Harwoko UNSPECIFIED orcid.org/0000-0002-4111-7147 UNSPECIFIED Lee, Jungho UNSPECIFIED UNSPECIFIED UNSPECIFIED Hartmann, Rudolf UNSPECIFIED UNSPECIFIED UNSPECIFIED Mandi, Attila UNSPECIFIED UNSPECIFIED UNSPECIFIED Kurtan, Tibor UNSPECIFIED UNSPECIFIED UNSPECIFIED Mueller, Werner E. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Feldbruegge, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Kalscheuer, Rainer UNSPECIFIED UNSPECIFIED UNSPECIFIED Ancheeva, Elena UNSPECIFIED UNSPECIFIED UNSPECIFIED Daletos, Georgios UNSPECIFIED UNSPECIFIED UNSPECIFIED Frank, Marian UNSPECIFIED orcid.org/0000-0003-3190-9076 UNSPECIFIED Liu, Zhen UNSPECIFIED UNSPECIFIED UNSPECIFIED Proksch, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-316247
DOI:	10.1016/j.fitote.2020.104698
Journal or Publication Title:	Fitoterapia
Volume:	146
Date:	2020
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1873-6971
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ABSOLUTE-CONFIGURATION; GINKGO-BILOBA; DERIVATIVES; METABOLITE Multiple languages Chemistry, Medicinal; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31624