Schwarze, Vincent ORCID: 0000-0003-3910-7801, Rubenthaler, Johannes ORCID: 0000-0003-0832-5662, Marschner, Constantin, Fabritius, Matthias Philipp, Rueckel, Johannes, Fink, Nicola, Puhr-Westerheide, Daniel, Gresser, Eva, Froelich, Matthias Frank, Schnitzer, Moritz Ludwig, Grosse Hokamp, Nils, Afat, Saif ORCID: 0000-0002-6861-6245, Staehler, Michael ORCID: 0000-0002-4574-6522, Geyer, Thomas and Clevert, Dirk-Andre (2020). Advanced Fusion Imaging and Contrast-Enhanced Imaging (CT/MRI-CEUS) in Oncology. Cancers, 12 (10). BASEL: MDPI. ISSN 2072-6694

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Abstract

Simple Summary Fusion imaging depicts an innovative technique by which previously performed computed tomography/magnetic resonance imaging can be integrated and reconstructed with advanced contrast-enhanced ultrasound using modern ultrasound devices in a real-time manner. Fusion imaging allows for complementing strengths and reducing restrictions of the combined imaging modalities. The visualization of parenchymal and tumoral microperfusion by contrast-enhanced ultrasound can be dynamically fused and assessed with images from previous cross-sectional studies and may help to decipher underlying entities of indeterminate lesions or validate suspicious morphology. The findings from our study demonstrate the benefits of fusion imaging for evaluating focal hepatic and renal lesions. The excellent safety profile, accessibility, repeatability and cost-effectiveness are advantages of fusion imaging which make it a powerful diagnostic tool for the modern radiologist. Fusion imaging depicts an innovative technique that facilitates combining assets and reducing restrictions of advanced ultrasound and cross-sectional imaging. The purpose of the present retrospective study was to evaluate the role of fusion imaging for assessing hepatic and renal lesions. Between 02/2011-08/2020, 92 patients in total were included in the study, of which 32 patients had hepatic lesions, 60 patients had renal lesions. Fusion imaging was technically successful in all patients. No adverse side effects upon intravenous (i.v.) application of SonoVue (R) (Bracco, Milan, Italy) were registered. Fusion imaging could clarify all 11 (100%) initially as indeterminate described hepatic lesions by computed tomography/magnetic resonance imaging (CT/MRI). Moreover, 5/14 (36%) initially suspicious hepatic lesions could be validated by fusion imaging, whereas in 8/14 (57%), malignant morphology was disproved. Moreover, fusion imaging allowed for the clarification of 29/30 (97%) renal lesions initially characterized as suspicious by CT/MRI, of which 19/30 (63%) underwent renal surgery, histopathology revealed malignancy in 16/19 (84%), and benignity in 3/19 (16%). Indeterminate findings could be elucidated by fusion imaging in 20/20 (100%) renal lesions. Its accessibility and repeatability, even during pregnancy and in childhood, its cost-effectiveness, and its excellent safety profile, make fusion imaging a promising instrument for the thorough evaluation of hepatic and renal lesions in the future.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Schwarze, VincentUNSPECIFIEDorcid.org/0000-0003-3910-7801UNSPECIFIED
Rubenthaler, JohannesUNSPECIFIEDorcid.org/0000-0003-0832-5662UNSPECIFIED
Marschner, ConstantinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fabritius, Matthias PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rueckel, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fink, NicolaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puhr-Westerheide, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gresser, EvaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Froelich, Matthias FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schnitzer, Moritz LudwigUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Grosse Hokamp, NilsUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Afat, SaifUNSPECIFIEDorcid.org/0000-0002-6861-6245UNSPECIFIED
Staehler, MichaelUNSPECIFIEDorcid.org/0000-0002-4574-6522UNSPECIFIED
Geyer, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clevert, Dirk-AndreUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-316362
DOI: 10.3390/cancers12102821
Journal or Publication Title: Cancers
Volume: 12
Number: 10
Date: 2020
Publisher: MDPI
Place of Publication: BASEL
ISSN: 2072-6694
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CYSTIC RENAL MASSES; STAGE HEPATOCELLULAR-CARCINOMA; FOCAL LIVER-LESIONS; ULTRASOUND CEUS; BOSNIAK CLASSIFICATION; COMPUTED-TOMOGRAPHY; RADIOFREQUENCY ABLATION; DIAGNOSIS; CT; MRIMultiple languages
OncologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31636

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