Universität zu Köln

Tichelbaecker, Tobias, Scherner, L., Puls, M., Schillinger, W., Adler, C., Baldus, S., Jacobshagen, C. and Huenlich, M. (2020). Midterm outcomes of LAA occlusion with the AMPLATZER Cardiac Plug and AMPLATZER Amulet devices in a high-risk cohort. Sci Rep, 10 (1). BERLIN: NATURE RESEARCH. ISSN 2045-2322

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Abstract

LAA occlusion has become a favourable option in patients with atrial fibrillation not eligible for oral anticoagulation therapy. Proof of effectiveness of LAA closure devices in a midterm follow-up period. This retrospective single-center cohort study analysed outcome in patients treated with AMPLATZER Cardiac Plug or AMPLATZER Amulet device. A standardized follow-up by phone call focusing on data of death, stroke and bleeding events was performed. Routine antiplatelet strategy was DAPT for 3 months post procedural. 212 patients (mean age 77 +/- 6 years) were included. Follow up was performed in 197 (93%) patients. Patients were at high risk for thromboembolic or bleeding events (prior stroke/TIA 29%; prior bleeding 54%. Overall, there was a mean follow-up period of 1244.2 days (+/- 756.7) and a total of 674 patient years. We observed 25 events later than day 8 post procedure. We were able to demonstrate a high effectiveness of the AMPLATZER Cardiac Plug/AMPLATZER Amulet devices regarding the prevention of stroke and bleedings in a high-risk real-world cohort during a midterm follow-up period. Overall, we observed remarkably lower rates of stroke and bleedings as predicted with CHA(2)DS(2)-VASc and HASBLED scores.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Tichelbaecker, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED Scherner, L. UNSPECIFIED UNSPECIFIED UNSPECIFIED Puls, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Schillinger, W. UNSPECIFIED UNSPECIFIED UNSPECIFIED Adler, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baldus, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Jacobshagen, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Huenlich, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-316843
DOI:	10.1038/s41598-020-73381-w
Journal or Publication Title:	Sci Rep
Volume:	10
Number:	1
Date:	2020
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	2045-2322
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ATRIAL APPENDAGE CLOSURE; WARFARIN Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31684