Universität zu Köln

Kresken, Michael, Korte-Berwanger, Miriam, Gatermann, Soeren G., Pfeifer, Yvonne, Pfennigwerth, Niels, Seifert, Harald and Werner, Guido (2020). In vitro activity of cefiderocol against aerobic Gram-negative bacterial pathogens from Germany. Int. J. Antimicrob. Agents, 56 (4). AMSTERDAM: ELSEVIER. ISSN 1872-7913

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Abstract

Objectives: Cefiderocol (CID), also known as S-649266, a novel siderophore cephalosporin, possesses potent activity against multidrug-resistant aerobic Gram-negative bacteria (GNB). This study aimed to determine the in vitro activity of CID against two different sets of GNB: i) a random sample of 213 clinical isolates, including 17 extended-spectrum beta-lactamase (ESBL) producers, obtained from intensive care unit patients with nosocomial infections collected during a multicentre surveillance study (set I); and ii) a group of 59 challenge GNB producing various types of carbapenemases (CP; set II). Methods: Minimum inhibitory concentrations (MICs) were determined using the microdilution method according to the standard ISO 20776-1. Iron-depleted medium was used for testing CID. Results: CID inhibited 97.2% of set I isolates at the EUCAST susceptibility breakpoint of <= 2 mg/L. The concentrations of CID inhibiting 50% and 90% (MIC50/90) of the Enterobacterales isolates (n = 146) were 0.12/1.0 mg/L, with ESBL-positive isolates tending to exhibit higher MICs than ESBL-negative isolates to CID. MIC50/90 values of CID for isolates of the Acinetobacter baumannii group (n = 13) and Pseudomonas aeruginosa (n = 54) were 0.06/0.12 mg/L and 0.12/0.5 mg/L, respectively. Further, CID inhibited 88.1% of set II CP-producing isolates at <= 2 mg/L. All seven class D CP-producing Acinetobacter baumannii were inhibited at < 0.25 mg/L. MIC50/90 values for CP-producing Enterobacterales (n = 30) and Pseudomonas aeruginosa (n = 22) were 1/4 mg/L and 0.5/2 mg/L, respectively. Conclusion: CID showed potent activity against Acinetobacter baumannii, Enterobacterales and Pseudomonas aeruginosa, including CP-producing isolates. Overall, CID inhibited 259 of 272 (95.2%) GNB at <= 2 mg/L. (C) 2020 The Authors. Published by Elsevier Ltd.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Kresken, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Korte-Berwanger, Miriam UNSPECIFIED UNSPECIFIED UNSPECIFIED Gatermann, Soeren G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfeifer, Yvonne UNSPECIFIED UNSPECIFIED UNSPECIFIED Pfennigwerth, Niels UNSPECIFIED UNSPECIFIED UNSPECIFIED Seifert, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Werner, Guido UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-317568
DOI:	10.1016/j.ijantimicag.2020.106128
Journal or Publication Title:	Int. J. Antimicrob. Agents
Volume:	56
Number:	4
Date:	2020
Publisher:	ELSEVIER
Place of Publication:	AMSTERDAM
ISSN:	1872-7913
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SIDEROPHORE CEPHALOSPORIN; ANTIBACTERIAL ACTIVITY; RESISTANCE; S-649266 Multiple languages Infectious Diseases; Microbiology; Pharmacology & Pharmacy Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31756