Universität zu Köln

Chatzidoukaki, Ourania, Goulielmaki, Evi, Schumacher, Bjoern and Garinis, George A. ORCID: 0000-0002-3200-5004 (2020). DNA Damage Response and Metabolic Reprogramming in Health and Disease. Trends Genet., 36 (10). S. 777 - 792. LONDON: ELSEVIER SCIENCE LONDON. ISSN 1362-4555

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Abstract

Nuclear DNA damage contributes to cellular malfunction and the premature onset of age-related diseases, including cancer. Until recently, the canonical DNA damage response (DDR) was thought to represent a collection of nuclear processes that detect, signal and repair damaged DNA. However, recent evidence suggests that beyond nuclear events, the DDR rewires an intricate network of metabolic circuits, fine-tunes protein synthesis, trafficking, and secretion as well as balances growth with defense strategies in response to genotoxic insults. In this review, we discuss how the active DDR signaling mobilizes extranuclear and systemic responses to promote cellular homeostasis and organismal survival in health and disease.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Chatzidoukaki, Ourania UNSPECIFIED UNSPECIFIED UNSPECIFIED Goulielmaki, Evi UNSPECIFIED UNSPECIFIED UNSPECIFIED Schumacher, Bjoern UNSPECIFIED UNSPECIFIED UNSPECIFIED Garinis, George A. UNSPECIFIED orcid.org/0000-0002-3200-5004 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-317663
DOI:	10.1016/j.tig.2020.06.018
Journal or Publication Title:	Trends Genet.
Volume:	36
Number:	10
Page Range:	S. 777 - 792
Date:	2020
Publisher:	ELSEVIER SCIENCE LONDON
Place of Publication:	LONDON
ISSN:	1362-4555
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NUCLEOTIDE EXCISION-REPAIR; UNFOLDED PROTEIN RESPONSE; DOUBLE-STRAND BREAKS; NUCLEAR-DNA; CELL-CYCLE; SIGNALING TRIGGERS; GENOTOXIC STRESS; GENE-EXPRESSION; GROWTH-HORMONE; I INTERFERON Multiple languages Genetics & Heredity Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31766