Universität zu Köln

Flores-Romero, Hector ORCID: 0000-0003-0996-5717 and Garcia-Saez, Ana J. (2020). Lipids glue BAK dimers together. Nat. Struct. Mol. Biol., 27 (11). S. 1003 - 1005. BERLIN: NATURE RESEARCH. ISSN 1545-9985

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Abstract

BAX and BAK oligomerize to mediate mitochondrial membrane permeabilization during apoptosis. A recent structure of the core domain of active BAK dimers with bound phospholipid molecules reveals a new bridging mechanism by which lipids drive BAX and BAK oligomerization and membrane pore formation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Flores-Romero, Hector UNSPECIFIED orcid.org/0000-0003-0996-5717 UNSPECIFIED Garcia-Saez, Ana J. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-318057
DOI:	10.1038/s41594-020-00516-y
Journal or Publication Title:	Nat. Struct. Mol. Biol.
Volume:	27
Number:	11
Page Range:	S. 1003 - 1005
Date:	2020
Publisher:	NATURE RESEARCH
Place of Publication:	BERLIN
ISSN:	1545-9985
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language OLIGOMERIZATION; MITOCHONDRIA; ACTIVATION; SEPARATE Multiple languages Biochemistry & Molecular Biology; Biophysics; Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31805