Loeser, Heike ORCID: 0000-0003-4555-1327, Kraemer, Max, Gebauer, Florian, Bruns, Christiane, Schroder, Wolfgang, Zander, Thomas, Alakus, Hakan, Hoelscher, Arnulf, Buettner, Reinhard, Lohneis, Philipp and Quaas, Alexander (2020). Indoleamine 2,3-Dioxygenase (IDO) Expression Is an Independent Prognostic Marker in Esophageal Adenocarcinoma. J Immunol. Res., 2020. LONDON: HINDAWI LTD. ISSN 2314-7156

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Abstract

Background. Indoleamine 2,3-dioxygenase (IDO) is an interferon-inducible immune checkpoint expressed on tumor-infiltrating lymphocytes (TILs). IDO is known as a poor prognostic marker in esophageal squamous cell cancer, while a positive effect was shown for breast cancer. A comprehensive analysis of IDO expression in a well-defined cohort of esophageal adenocarcinoma (EAC) is missing.Methods. We analyzed 551 patients with EAC using single-protein and multiplex immunohistochemistry as well as mRNA in situ technology for the expression and distribution of IDO on subtypes of TILs (INF-gamma mRNA and CD4- and CD8-positive T lymphocytes).Results. IDO expression on TILs was seen in up to 59.6% of tumors, and expression on tumor cells was seen in 9.2%. We found a strong positive correlation of IDO-positive TILs, CD3-positive T lymphocytes, and INF-gamma mRNA-producing TILs in the tumor microenvironment of EACs showing significantly better overall survival (47.7 vs. 22.7 months,p<0.001) with emphasis on early tumor stages (pT1/2: 142.1 vs. 37.1 months,p<0.001). In multivariate analysis, IDO is identified as an independent prognostic marker.Conclusions. Our study emphasizes the importance of immunomodulation in EAC marking IDO as a potential biomarker. Beyond this, IDO might indicate a subgroup of EAC with an explicit survival benefit.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Loeser, HeikeUNSPECIFIEDorcid.org/0000-0003-4555-1327UNSPECIFIED
Kraemer, MaxUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gebauer, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bruns, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schroder, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zander, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alakus, HakanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hoelscher, ArnulfUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Buettner, ReinhardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lohneis, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Quaas, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-318563
DOI: 10.1155/2020/2862647
Journal or Publication Title: J Immunol. Res.
Volume: 2020
Date: 2020
Publisher: HINDAWI LTD
Place of Publication: LONDON
ISSN: 2314-7156
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
TUMOR-INFILTRATING LYMPHOCYTES; STANDARDIZED METHOD; INTERFERON-GAMMA; SOLID TUMORS; CANCER; SURVIVAL; CHEMORADIATION; PATHOLOGISTS; CARCINOMA; PROPOSALMultiple languages
ImmunologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31856

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