Universität zu Köln

Loosen, Sven H., Wirtz, Theresa H., Roy, Sanchari, Vucur, Mihael, Castoldi, Mirco, Schneider, Anne T., Koppe, Christiane, Ulmer, Tom F., Roeth, Anjali A., Bednarsch, Jan, Alizai, Patrick H., Paffenholz, Pia, Demir, Muenevver, Trautwein, Christian, Tacke, Frank, Neumann, Ulf P., Roderburg, Christoph and Luedde, Tom (2020). Circulating levels of microRNA193a-5p predict outcome in early stage hepatocellular carcinoma. PLoS One, 15 (9). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

While tumor resection and liver transplantation (LT) represent potentially curative therapeutic options for patients with early-stage hepatocellular carcinoma (HCC), the identification of the ideal surgical candidates has remained challenging. Just recently, miRNA-193a-5p was described as a tumor suppressor in murine and human HCC but only little is known about circulating miRNA-193a-5p in HCC patients. Here, we evaluated serum levels of miR-193a-5p by qPCR in 41 HCC patients undergoing tumor resection (n = 33) or LT (n = 8) and 20 controls. Circulating relative miR-193a-5p levels were significantly elevated in HCC patients compared to healthy controls. While relative miR-193a-5p levels were comparable between patients of different underlying disease etiology and tumor size, high relative miR-193a-5p levels were predictive for the patients' postoperative outcome, which was confirmed in uni- and multivariate Cox-regression analysis. As such, HCC patients with a preoperative relative miR-193a-5p level above the ideal cut-off value (3.57) had a median overall survival (OS) of only 451 days compared to 1158 days in patients with a relative miR-193a-5p level below this cut-off value. Our data support a novel function of miR-193a-5p as a biomarker in early-stage HCC patients that might help to identify the best surgical candidates in terms of postoperative outcome.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Loosen, Sven H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wirtz, Theresa H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roy, Sanchari UNSPECIFIED UNSPECIFIED UNSPECIFIED Vucur, Mihael UNSPECIFIED UNSPECIFIED UNSPECIFIED Castoldi, Mirco UNSPECIFIED UNSPECIFIED UNSPECIFIED Schneider, Anne T. UNSPECIFIED UNSPECIFIED UNSPECIFIED Koppe, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Ulmer, Tom F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roeth, Anjali A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bednarsch, Jan UNSPECIFIED UNSPECIFIED UNSPECIFIED Alizai, Patrick H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paffenholz, Pia UNSPECIFIED UNSPECIFIED UNSPECIFIED Demir, Muenevver UNSPECIFIED UNSPECIFIED UNSPECIFIED Trautwein, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Tacke, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Neumann, Ulf P. UNSPECIFIED UNSPECIFIED UNSPECIFIED Roderburg, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Luedde, Tom UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-318582
DOI:	10.1371/journal.pone.0239386
Journal or Publication Title:	PLoS One
Volume:	15
Number:	9
Date:	2020
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER; GENES Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31858