Universität zu Köln

Meyer, M. F., Arolt, C., Kansy, B. A., Doescher, J., Quaas, A., Beutner, D., Lang, S. and Klussmann, J. P. (2020). Tumor microenvironment in salivary gland carcinomas: Consequences for new therapeutic concepts. HNO, 68 (12). S. 927 - 935. NEW YORK: SPRINGER. ISSN 1433-0458

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Abstract

Introduction Salivary gland carcinomas (SGCs) are rare tumors which represent a challenge for diagnosis and therapy due to their histological diversity and the different disease courses depending on the respective subtype. Little is known about the composition of the tumor microenvironment in SGCs. A more comprehensive understanding of the relevant molecular changes and immunological processes of the tumor and surrounding stroma could help to improve therapeutic efficiency, for example by adjuvant immunomodulation. Methods This manuscript highlights recent studies analyzing the composition of the tumor microenvironment in salivary gland carcinomas. Results The tumor microenvironment displays a significant diversity in the composition of immune cells among different tumor entities. In one third of the SGCs, an expression of cell surface molecule LAG3 on tumor infiltrating lymphocytes could be observed. LAG3-similar to CTLA-4 and PD-1-inhibits cellular proliferation, activation, and homeostasis of antitumor-effective T cells. Especially, prognostically less favorable entities such as salivary duct carcinomas and adenocarcinomas NOS (not otherwise specified) yielded higher expressions. Conclusions LAG3 is particularly detectable in aggressive entities and advanced tumors. Hence, LAG3 inhibition poses a potential targeted therapy for advanced and metastatic SGCs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Meyer, M. F. UNSPECIFIED UNSPECIFIED UNSPECIFIED Arolt, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Kansy, B. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Doescher, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Quaas, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Beutner, D. UNSPECIFIED UNSPECIFIED UNSPECIFIED Lang, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Klussmann, J. P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-319170
DOI:	10.1007/s00106-020-00926-w
Journal or Publication Title:	HNO
Volume:	68
Number:	12
Page Range:	S. 927 - 935
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1433-0458
Language:	German
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CANCER; OVEREXPRESSION; MECHANISMS; EXPRESSION; DIAGNOSIS; PD-L2; HEAD Multiple languages Otorhinolaryngology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31917