Miura, Mizuki, Alessandrini, Hannes, Alkhodair, Abdullah, Attinger-Toller, Adrian, Biasco, Luigi, Lurz, Philipp, Braun, Daniel, Brochet, Eric, Connelly, Kim A., de Bruijn, Sabine, Denti, Paolo, Deuschl, Florian, Estevez-Loureiro, Rodrigo, Fam, Neil, Frerker, Christian, Gavazzoni, Mara, Hausleiter, Jorg, Himbert, Dominique, Ho, Edwin, Juliard, Jean-Michel, Kaple, Ryan, Besler, Christian, Kodali, Susheel, Kreidel, Felix, Kuck, Karl-Heinz, Latib, Azeem, Lauten, Alexander, Monivas, Vanessa, Mehr, Michael, Muntane-Carol, Guillem, Nazif, Tamin, Nickenig, Georg, Pedrazzini, Giovanni, Philippon, Francois, Pozzoli, Alberto, Praz, Fabien, Puri, Rishi, Rodes-Cabau, Josep, Schafer, Ulrich, Schofer, Joachim, Sievert, Horst, Tang, Gilbert H. L., Thiele, Holger ORCID: 0000-0002-0169-998X, Rommel, Karl-Philipp, Vahanian, Alec, Von Bardeleben, Ralph Stephan, Webb, John G., Weber, Marcel ORCID: 0000-0003-4100-9522, Windecker, Stephan, Winkel, Mirjam, Zuber, Michel, Leon, Martin B., Maisano, Francesco ORCID: 0000-0002-3691-1709, Hahn, Rebecca T. and Taramasso, Maurizio (2020). Impact of Massive or Torrential Tricuspid Regurgitation in Patients Undergoing Transcatheter Tricuspid Valve Intervention. JACC-Cardiovasc. Interv., 13 (17). S. 1999 - 2010. NEW YORK: ELSEVIER SCIENCE INC. ISSN 1876-7605

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Abstract

OBJECTIVES The aim of this study was to assess the clinical outcome of baseline massive or torrential tricuspid regurgitation (TR) after transcatheter tricuspid valve intervention (TTVI). BACKGROUND The use of TTVI to treat symptomatic severe TR has been increasing rapidly, but little is known regarding the impact of massive or torrential TR beyond severe TR. METHODS The study population comprised 333 patients with significant symptomatic TR from the TriValve Registry who underwent TTVI. Mid-term outcomes after TTVI were assessed according to the presence of massive or torrential TR, defined as vena contracta width >= 14 mm. Procedural success was defined as patient survival after successful device implantation and delivery system retrieval, with residual TR <= 2+. The primary endpoint comprised survival rate and freedom from rehospitalization for heart failure, survival rate, and rehospitalization at 1 year. RESULTS Baseline massive or torrential TR and severe TR were observed in 154 patients (46.2%) and 179 patients (53.8%), respectively. Patients with massive or torrential TR had a higher prevalence of ascites than those with severe TR (27.3% vs. 20.4%, respectively; p = 0.15) and demonstrated a similar procedural success rate (83.2% vs. 77.3%, respectively; p = 0.21). The incidence of peri-procedural adverse events was low, with no significant between-group differences. Freedom from the composite endpoint was significantly tower in patients with massive or torrential TR than in those with severe TR, which was significantly associated with an increased risk for 1-year death of any cause or rehospitalization for heart failure (adjusted hazard ratio:1.91; 95% confidence interval:1.10 to 3.34; p = 0.022). Freedom from the composite endpoint was significantly higher in patients with massive or torrential TR when procedural success was achieved (69.9% vs. 54.2%, p = 0.048). CONCLUSIONS Baseline massive or torrential TR is associated with an increased risk for all-cause mortality and rehospitalization for heart failure 1 year after TTVI. Procedural success is related to better outcomes, even in the presence of baseline massive or torrential TR. (C) 2020 by the American College of Cardiology Foundation.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Miura, MizukiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alessandrini, HannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Alkhodair, AbdullahUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attinger-Toller, AdrianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Biasco, LuigiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lurz, PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Braun, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Brochet, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Connelly, Kim A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Bruijn, SabineUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Denti, PaoloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Deuschl, FlorianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Estevez-Loureiro, RodrigoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fam, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frerker, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gavazzoni, MaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hausleiter, JorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Himbert, DominiqueUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ho, EdwinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juliard, Jean-MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kaple, RyanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Besler, ChristianUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kodali, SusheelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kreidel, FelixUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kuck, Karl-HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Latib, AzeemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lauten, AlexanderUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Monivas, VanessaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mehr, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muntane-Carol, GuillemUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nazif, TaminUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Nickenig, GeorgUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pedrazzini, GiovanniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Philippon, FrancoisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pozzoli, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Praz, FabienUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puri, RishiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rodes-Cabau, JosepUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schafer, UlrichUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schofer, JoachimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sievert, HorstUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tang, Gilbert H. L.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Thiele, HolgerUNSPECIFIEDorcid.org/0000-0002-0169-998XUNSPECIFIED
Rommel, Karl-PhilippUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Vahanian, AlecUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Von Bardeleben, Ralph StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Webb, John G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Weber, MarcelUNSPECIFIEDorcid.org/0000-0003-4100-9522UNSPECIFIED
Windecker, StephanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Winkel, MirjamUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Zuber, MichelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leon, Martin B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maisano, FrancescoUNSPECIFIEDorcid.org/0000-0002-3691-1709UNSPECIFIED
Hahn, Rebecca T.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taramasso, MaurizioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-319212
DOI: 10.1016/j.jcin.2020.05.011
Journal or Publication Title: JACC-Cardiovasc. Interv.
Volume: 13
Number: 17
Page Range: S. 1999 - 2010
Date: 2020
Publisher: ELSEVIER SCIENCE INC
Place of Publication: NEW YORK
ISSN: 1876-7605
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
NATIVE VALVULAR REGURGITATION; EUROPEAN ASSOCIATION; REPAIR; ANNULOPLASTY; FEASIBILITY; OUTCOMES; RECOMMENDATIONS; MANAGEMENT; SOCIETY; SURGERYMultiple languages
Cardiac & Cardiovascular SystemsMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/31921

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