Universität zu Köln

Marissen, Janina, Erdmann, Harald, Boeckenholt, Kai, Hoppenz, Marc, Rausch, Tanja K., Haertel, Christoph, Herting, Egbert and Goepel, Wolfgang . Aminoglycosides were associated with higher rates of surgical patent ductus arteriosus closure in preterm infants. Acta Paediatr.. HOBOKEN: WILEY. ISSN 1651-2227

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Abstract

Aim In animal studies, aminoglycosides induced ductus arteriosus relaxation in a dose-dependent fashion. We tested the hypothesis that antibiotic treatment of preterm infants with aminoglycosides is associated with higher rates of surgical patent ductus arteriosus (PDA) closure. Methods Preterm infants (birthweight <1000 grams or gestational age <29 weeks) enrolled in 62 German neonatal intensive care units (NICUs) were analysed. NICUs were stratified according to the use of aminoglycosides as first-line antibiotics. Results Baseline data were not different when NICUs using aminoglycosides (n = 9965 infants) were compared to NICUs using other antibiotics (n = 1948 infants). Rates of surgical PDA closure were 5.9% for NICUs using aminoglycosides; 6.2% for units using gentamicin; and 5.0% for NICUs using tobramycin compared to 4.1% in NICUs using other antibiotics (P < .001,P P = .140, respectively, Fisher's exact test). Indomethacin and ibuprofen use was more common in NICUs using aminoglycosides (41% vs 33%,P < .001, Fisher's exact test). Gentamicin trough levels were higher in NICUs with surgical closure rates above the mean (median 2.0 mu g/mL, inter-quartile range 0.8-4.0 mu g/mL vs 1.2 mu g/mL, IQR 0.8-1.7,P < .001, Mann-WhitneyUtest). Conclusion First-line antibiotic treatment of preterm infants with aminoglycosides was associated with higher rates of surgical PDA closure.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Marissen, Janina UNSPECIFIED UNSPECIFIED UNSPECIFIED Erdmann, Harald UNSPECIFIED UNSPECIFIED UNSPECIFIED Boeckenholt, Kai UNSPECIFIED UNSPECIFIED UNSPECIFIED Hoppenz, Marc UNSPECIFIED UNSPECIFIED UNSPECIFIED Rausch, Tanja K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haertel, Christoph UNSPECIFIED UNSPECIFIED UNSPECIFIED Herting, Egbert UNSPECIFIED UNSPECIFIED UNSPECIFIED Goepel, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-319626
DOI:	10.1111/apa.15541
Journal or Publication Title:	Acta Paediatr.
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1651-2227
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GENTAMICIN; PHARMACOKINETICS; RELAXATION; MORTALITY; SEPSIS Multiple languages Pediatrics Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31962