Universität zu Köln

Sitnilska, Vasilena, Enders, Philip, Cursiefen, Claus, Fauser, Sascha and Altay, Lebriz . Association of imaging biomarkers and local activation of complement in aqueous humor of patients with early forms of age-related macular degeneration. Graefes Arch. Clin. Exp. Ophthalmol.. NEW YORK: SPRINGER. ISSN 1435-702X

Full text not available from this repository.

Abstract

Purpose To investigate a possible correlation between established imaging biomarkers for age-related macular degeneration and local complement system activation, measured in aqueous humor (AH) of patients with early stages of age-related macular degeneration (AMD) and controls. Methods This analysis included prospectively acquired AH samples of 106 eyes (35 with early/intermediate AMD, 71 controls). The levels of complement protein 3 (C3), 4 (C4), 5 (C5); activation products of complement factor 3a (C3a) and Ba, C3b/iC3b; complement factors B, D, H, I (CFB, CFD, CFH, CFI); and total protein concentration were analyzed. Quantitative levels of complement factors were correlated to the presence of reticular pseudodrusen (RPD), the presence of hyperreflective foci (HRF), and total drusen volume (DV) graded on imaging by spectral-domain optical coherence tomography and using Spearman's rank correlation test. Results DV correlated with C3b/iC3b (r= 0.285;P= 0.034), C3a (r= 0.200;P= 0.047), Ba (r= 0.262;P= 0.009), and C5 (r= 430;P= 0.005), and showed a tendency towards correlation with C3a (r= 0.198;P= 0.057). HRF correlated significantly with C5 (r= 0.388;P= 0.011) and RPD showed a tendency towards correlation with CFB (r= 0.196;P= 0.050). Conclusion In patients with early AMD, HRF and drusen parameters but not RPD show low to fair levels of correlation with local complement activation in patients' AH. Better understanding of complement activation could provide some insights into the pathogenesis of AMD. Imaging biomarkers could be useful to identify suitable patients for future clinical trials with complement-modulating therapies.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sitnilska, Vasilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Fauser, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Altay, Lebriz UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-319904
DOI:	10.1007/s00417-020-04910-6
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language SUBRETINAL DRUSENOID DEPOSITS; OPTICAL COHERENCE TOMOGRAPHY; RETICULAR PSEUDODRUSEN; HYPERREFLECTIVE FOCI; PROGRESSION; PREVALENCE; DISEASE; COMMON; RISK; OCT Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/31990