Universität zu Köln

Willemsen, David, Cui, Rongfeng, Reichard, Martin and Valenzano, Dario Riccardo ORCID: 0000-0002-8761-8289 (2020). Intra-species differences in population size shape life history and genome evolution. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

The evolutionary forces shaping life history divergence within species are largely unknown. Turquoise killifish display differences in lifespan among wild populations, representing an ideal natural experiment in evolution and diversification of life history. By combining genome sequencing and population genetics, we investigate the evolutionary forces shaping lifespan among wild turquoise killifish populations. We generate an improved reference genome assembly and identify genes under positive and purifying selection, as well as those evolving neutrally. Short-lived populations from the outer margin of the species range have small population size and accumulate deleterious mutations in genes significantly enriched in the WNT signaling pathway, neurodegeneration, cancer and the mTOR pathway. We propose that limited population size due to habitat fragmentation and repeated population bottlenecks, by increasing the genome-wide mutation load, exacerbates the effects of mutation accumulation and cumulatively contribute to the short adult lifespan.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Willemsen, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Cui, Rongfeng UNSPECIFIED UNSPECIFIED UNSPECIFIED Reichard, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Valenzano, Dario Riccardo UNSPECIFIED orcid.org/0000-0002-8761-8289 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-321667
DOI:	10.7554/eLife.55794
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FISH NOTHOBRANCHIUS-FURZERI; AFRICAN TURQUOISE KILLIFISH; ADAPTIVE PROTEIN EVOLUTION; VERTEBRATE MODEL; DIFFERENTIATION; IDENTIFICATION; ALIGNMENT; GENERATION; ASSEMBLIES; INFERENCE Multiple languages Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32166