Universität zu Köln

Rink, Svenja, Chatziparaskeva, Christina, Elles, Luisa, Pavlov, Stoyan ORCID: 0000-0002-9322-2299, Nohroudi, Klaus, Bendella, Habib, Sarikcioglu, Levent, Manthou, Marilena, Dunlop, Sarah ORCID: 0000-0002-1306-3962, Gordon, Tessa and Angelov, Doychin N. (2020). Neutralizing BDNF and FGF2 injection into denervated skeletal muscle improve recovery after nerve repair. Muscle Nerve, 62 (3). S. 404 - 413. HOBOKEN: WILEY. ISSN 1097-4598

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Abstract

Background: After facial nerve injury and surgical repair in rats, recovery of vibrissal whisking is associated with a high proportion of mono-innervated neuro-muscular junctions (NMJs). Our earlier work with Sprague Dawley (SD)/Royal College of Surgeons (RCS) rats, which are blind and spontaneously restore NMJ-monoinnervation and whisking, showed correlations between functional recovery and increase of fibroblast growth factor-2 (FGF2) and brain-derived neurotrophic factor (BDNF) in denervated vibrissal muscles. Methods: We used normally sighted rats (Wistar), in which NMJ-polyinnervation is highly correlated with poor whisking recovery, and injected the vibrissal muscle levator labii superioris (LLS) with combinations of BDNF, anti-BDNF, and FGF2 at different postoperative periods after facial nerve injury. Results: Rats receiving anti-BDNF+FGF2 showed low NMJ-polyinnervation and best recovery of whisking amplitude. Conclusions: Restoration of target reinnervation after peripheral nerve injury requires a complex mixture of trophic factors with a specific time course of availability for each of them.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rink, Svenja UNSPECIFIED UNSPECIFIED UNSPECIFIED Chatziparaskeva, Christina UNSPECIFIED UNSPECIFIED UNSPECIFIED Elles, Luisa UNSPECIFIED UNSPECIFIED UNSPECIFIED Pavlov, Stoyan UNSPECIFIED orcid.org/0000-0002-9322-2299 UNSPECIFIED Nohroudi, Klaus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bendella, Habib UNSPECIFIED UNSPECIFIED UNSPECIFIED Sarikcioglu, Levent UNSPECIFIED UNSPECIFIED UNSPECIFIED Manthou, Marilena UNSPECIFIED UNSPECIFIED UNSPECIFIED Dunlop, Sarah UNSPECIFIED orcid.org/0000-0002-1306-3962 UNSPECIFIED Gordon, Tessa UNSPECIFIED UNSPECIFIED UNSPECIFIED Angelov, Doychin N. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-322165
DOI:	10.1002/mus.26991
Journal or Publication Title:	Muscle Nerve
Volume:	62
Number:	3
Page Range:	S. 404 - 413
Date:	2020
Publisher:	WILEY
Place of Publication:	HOBOKEN
ISSN:	1097-4598
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FIBROBLAST-GROWTH-FACTOR; TERMINAL SCHWANN-CELLS; IN-VIVO OBSERVATIONS; NEUROTROPHIC FACTOR; AXONAL REGENERATION; POSTSYNAPTIC CHANGES; FUNCTIONAL RECOVERY; VIBRISSAL MOVEMENT; TROPHIC FACTORS; RAT Multiple languages Clinical Neurology; Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32216