Apel, K., Puetz, K., Tolkach, Y., Canbay, A. and Drebber, U. (2020). Drug-induced liver injury-significance of pathology. Pathologe, 41 (5). S. 457 - 471. HEIDELBERG: SPRINGER HEIDELBERG. ISSN 1432-1963

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Abstract

Many different medical agents, herbal products, and dietary supplements can induce drug-induced liver injury (DILI) as a clinically relevant complication. DILI, which is direct toxic or idiosyncratic, can have a broad spectrum of clinical appearances from elevation of liver enzymes to acute liver failure. DILI is categorized clinically according to the pattern of serum parameters or pathologically according to the pattern of histomorphology. Histopathological patterns can be described as hepatitic, granulomatous, cholestatic, ductopenic, fibrotic, steatotic, steatohepatitic, and vascular. Correlation to the corresponding drug can be carried out with the corresponding databases (US National Library of Medicine, Liver Tox;). Liver biopsy, in contrast to a clinical/serological diagnostic, has the advantage of an exact resolution with evidence of pathophysiology, activity, regeneration, chronification, and prognosis. Co-occurrence of underlying liver disease can be excluded or confirmed. Histological patterns of DILI are described and illustrated. A diagnostic algorithm for the interpretation of liver biopsies is provided.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Apel, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Puetz, K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tolkach, Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Canbay, A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drebber, U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-322988
DOI: 10.1007/s00292-020-00811-x
Journal or Publication Title: Pathologe
Volume: 41
Number: 5
Page Range: S. 457 - 471
Date: 2020
Publisher: SPRINGER HEIDELBERG
Place of Publication: HEIDELBERG
ISSN: 1432-1963
Language: German
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
SINUSOIDAL DILATATION; FAILURE; DISEASE; CHOLANGITIS; GRANULOMAS; BIOPSYMultiple languages
PathologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32298

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