Universität zu Köln

Roberts, S. E., Thorne, K., Thapar, N., Broekaert, I., Benninga, M. A., Dolinsek, J., Mas, E., Miele, E., Orel, R., Pienar, C., Ribes-Koninckx, C., Thomson, M., Tzivinikos, C., Morrison-Rees, S., John, A. and Williams, J. G. (2020). A Systematic Review and Meta-analysis of Paediatric Inflammatory Bowel Disease Incidence and Prevalence Across Europe. J. Crohns Colitis, 14 (8). S. 1119 - 1149. OXFORD: OXFORD UNIV PRESS. ISSN 1876-4479

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Abstract

Background and Aims: Inflammatory bowel disease [IBD] is often one of the most devastating and debilitating chronic gastrointestinal disorders in children and adolescents. The main objectives here were to systematically review the incidence and prevalence of paediatric IBD across all 51 European states. Methods: We undertook a systematic review and meta-analysis based on PubMed, CINAHL, the Cochrane Library, searches of reference lists, grey literature and websites, covering the period from 1970 to 2018. Results: Incidence rates for both paediatric Crohn's disease [CD] and ulcerative colitis [UC] were higher in northern Europe than in other European regions. There have been large increases in the incidence of both paediatric CD and UC over the last 50 years, which appear widespread across Europe. The largest increases for CD have been reported from Sweden, Wales, England, the Czech Republic, Denmark and Hungary, and for UC from the Czech Republic, Ireland, Sweden and Hungary. Incidence rates for paediatric CD have increased up to 9 or 10 per 100 000 population in parts of Europe, including Scandinavia, while rates for paediatric UC are often slightly lower than for CD. Prevalence reported for CD ranged from 8.2 per 100 000 to approximately 60 and, for UC, from 8.3 to approximately 30. Conclusions: The incidence of paediatric IBD continues to increase throughout Europe. There is stronger evidence of a north-south than an east-west gradient in incidence across Europe. Further prospective studies are needed, preferably multinational and based on IBD registries, using standardized definitions, methodology and timescales.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Roberts, S. E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thorne, K. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thapar, N. UNSPECIFIED UNSPECIFIED UNSPECIFIED Broekaert, I. UNSPECIFIED UNSPECIFIED UNSPECIFIED Benninga, M. A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dolinsek, J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Mas, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Miele, E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Orel, R. UNSPECIFIED UNSPECIFIED UNSPECIFIED Pienar, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ribes-Koninckx, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Thomson, M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Tzivinikos, C. UNSPECIFIED UNSPECIFIED UNSPECIFIED Morrison-Rees, S. UNSPECIFIED UNSPECIFIED UNSPECIFIED John, A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Williams, J. G. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-324183
DOI:	10.1093/ecco-jcc/jjaa037
Journal or Publication Title:	J. Crohns Colitis
Volume:	14
Number:	8
Page Range:	S. 1119 - 1149
Date:	2020
Publisher:	OXFORD UNIV PRESS
Place of Publication:	OXFORD
ISSN:	1876-4479
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ONSET CROHNS-DISEASE; POPULATION-BASED INCEPTION; DRUG-TREATMENT PRACTICES; ULCERATIVE-COLITIS; INCREASING INCIDENCE; SOUTHEASTERN NORWAY; RISING INCIDENCE; WESTERN HUNGARY; FOLLOW-UP; EPIDEMIOLOGIC ASPECTS Multiple languages Gastroenterology & Hepatology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32418