Universität zu Köln

Rhein, Cosima, Muhle, Christiane, Lenz, Bernd ORCID: 0000-0001-6086-0924, Richter-Schmidinger, Tanja, Kogias, Georgios, Boix, Fernando, Lourdusamy, Anbarasu ORCID: 0000-0002-1978-6301, Dorfler, Arnd, Peters, Oliver, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Jessen, Frank, Maier, Wolfgang, Hull, Michael, Frolich, Lutz, Teipel, Stefan, Wiltfang, Jens, Kornhuber, Johannes and Muller, Christian P. (2020). Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly. Brain Res. Bull., 161. S. 13 - 21. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-2747

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Abstract

Calcium/Calmodulin-dependent kinase alpha (alpha CaMKII) has been shown to play an essential role in synaptic plasticity and in learning and memory in animal models. However, there is little evidence for an involvement in specific memories in humans. Here we tested the potential involvement of the alpha CaMKII coding gene CAMK2A in verbal logical memory in two Caucasian populations from Germany, in a sample of 209 elderly people with cognitive impairments and a sample of 142 healthy adults. The association of single nucleotide polymorphisms (SNPs) located within the genomic region of CAMK2A with verbal logical memory learning and retrieval from the Wechsler Memory Scale was measured and hippocampal volume was assessed by structural MRI. In the elderly people, we found the minor allele of CAMK2A intronic SNP rs919741 to predict a higher hippocampal volume and better logical memory retrieval. This association was not found in healthy adults. The present study may provide evidence for an association of a genetic variant of the CAMK2A gene specifically with retrieval of logical memory in elderly humans. This effect is possibly mediated by a higher hippocampal volume.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rhein, Cosima UNSPECIFIED UNSPECIFIED UNSPECIFIED Muhle, Christiane UNSPECIFIED UNSPECIFIED UNSPECIFIED Lenz, Bernd UNSPECIFIED orcid.org/0000-0001-6086-0924 UNSPECIFIED Richter-Schmidinger, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Kogias, Georgios UNSPECIFIED UNSPECIFIED UNSPECIFIED Boix, Fernando UNSPECIFIED UNSPECIFIED UNSPECIFIED Lourdusamy, Anbarasu UNSPECIFIED orcid.org/0000-0002-1978-6301 UNSPECIFIED Dorfler, Arnd UNSPECIFIED UNSPECIFIED UNSPECIFIED Peters, Oliver UNSPECIFIED UNSPECIFIED UNSPECIFIED Ramirez, Alfredo UNSPECIFIED orcid.org/0000-0003-4991-763X UNSPECIFIED Jessen, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Maier, Wolfgang UNSPECIFIED UNSPECIFIED UNSPECIFIED Hull, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Frolich, Lutz UNSPECIFIED UNSPECIFIED UNSPECIFIED Teipel, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiltfang, Jens UNSPECIFIED UNSPECIFIED UNSPECIFIED Kornhuber, Johannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Muller, Christian P. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-325408
DOI:	10.1016/j.brainresbull.2020.05.001
Journal or Publication Title:	Brain Res. Bull.
Volume:	161
Page Range:	S. 13 - 21
Date:	2020
Publisher:	PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication:	OXFORD
ISSN:	1873-2747
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DEPENDENT PROTEIN-KINASE; MEDIAL TEMPORAL-LOBE; ALPHA-CAMKII; AUTOPHOSPHORYLATION CONTROLS; MECHANISMS; ALCOHOL; ESTABLISHMENT; POTENTIATION; RELIABILITY; ADDICTION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32540