Rhein, Cosima, Muhle, Christiane, Lenz, Bernd ORCID: 0000-0001-6086-0924, Richter-Schmidinger, Tanja, Kogias, Georgios, Boix, Fernando, Lourdusamy, Anbarasu ORCID: 0000-0002-1978-6301, Dorfler, Arnd, Peters, Oliver, Ramirez, Alfredo ORCID: 0000-0003-4991-763X, Jessen, Frank, Maier, Wolfgang, Hull, Michael, Frolich, Lutz, Teipel, Stefan, Wiltfang, Jens, Kornhuber, Johannes and Muller, Christian P. (2020). Association of a CAMK2A genetic variant with logical memory performance and hippocampal volume in the elderly. Brain Res. Bull., 161. S. 13 - 21. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. ISSN 1873-2747

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Abstract

Calcium/Calmodulin-dependent kinase alpha (alpha CaMKII) has been shown to play an essential role in synaptic plasticity and in learning and memory in animal models. However, there is little evidence for an involvement in specific memories in humans. Here we tested the potential involvement of the alpha CaMKII coding gene CAMK2A in verbal logical memory in two Caucasian populations from Germany, in a sample of 209 elderly people with cognitive impairments and a sample of 142 healthy adults. The association of single nucleotide polymorphisms (SNPs) located within the genomic region of CAMK2A with verbal logical memory learning and retrieval from the Wechsler Memory Scale was measured and hippocampal volume was assessed by structural MRI. In the elderly people, we found the minor allele of CAMK2A intronic SNP rs919741 to predict a higher hippocampal volume and better logical memory retrieval. This association was not found in healthy adults. The present study may provide evidence for an association of a genetic variant of the CAMK2A gene specifically with retrieval of logical memory in elderly humans. This effect is possibly mediated by a higher hippocampal volume.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Rhein, CosimaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muhle, ChristianeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lenz, BerndUNSPECIFIEDorcid.org/0000-0001-6086-0924UNSPECIFIED
Richter-Schmidinger, TanjaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kogias, GeorgiosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Boix, FernandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Lourdusamy, AnbarasuUNSPECIFIEDorcid.org/0000-0002-1978-6301UNSPECIFIED
Dorfler, ArndUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Peters, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ramirez, AlfredoUNSPECIFIEDorcid.org/0000-0003-4991-763XUNSPECIFIED
Jessen, FrankUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maier, WolfgangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hull, MichaelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frolich, LutzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teipel, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Wiltfang, JensUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kornhuber, JohannesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Muller, Christian P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-325408
DOI: 10.1016/j.brainresbull.2020.05.001
Journal or Publication Title: Brain Res. Bull.
Volume: 161
Page Range: S. 13 - 21
Date: 2020
Publisher: PERGAMON-ELSEVIER SCIENCE LTD
Place of Publication: OXFORD
ISSN: 1873-2747
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
DEPENDENT PROTEIN-KINASE; MEDIAL TEMPORAL-LOBE; ALPHA-CAMKII; AUTOPHOSPHORYLATION CONTROLS; MECHANISMS; ALCOHOL; ESTABLISHMENT; POTENTIATION; RELIABILITY; ADDICTIONMultiple languages
NeurosciencesMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/32540

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