Universität zu Köln

Heger, Peter ORCID: 0000-0003-2583-2981, Zheng, Wen, Rottmann, Anna, Panfilio, Kristen A. and Wiehe, Thomas ORCID: 0000-0002-8932-2772 (2020). The genetic factors of bilaterian evolution. eLife, 9. CAMBRIDGE: ELIFE SCIENCES PUBLICATIONS LTD. ISSN 2050-084X

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Abstract

The Cambrian explosion was a unique animal radiation similar to 540 million years ago that produced the full range of body plans across bilaterians. The genetic mechanisms underlying these events are unknown, leaving a fundamental question in evolutionary biology unanswered. Using large-scale comparative genomics and advanced orthology evaluation techniques, we identified 157 bilaterian-specific genes. They include the entire Nodal pathway, a key regulator of mesoderm development and left-right axis specification; components for nervous system development, including a suite of G-protein-coupled receptors that control physiology and behaviour, the Robo-Slit midline repulsion system, and the neurotrophin signalling system; a high number of zinc finger transcription factors; and novel factors that previously escaped attention. Contradicting the current view, our study reveals that genes with bilaterian origin are robustly associated with key features in extant bilaterians, suggesting a causal relationship.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Heger, Peter UNSPECIFIED orcid.org/0000-0003-2583-2981 UNSPECIFIED Zheng, Wen UNSPECIFIED UNSPECIFIED UNSPECIFIED Rottmann, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Panfilio, Kristen A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Wiehe, Thomas UNSPECIFIED orcid.org/0000-0002-8932-2772 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-326214
DOI:	10.7554/eLife.45530
Journal or Publication Title:	eLife
Volume:	9
Date:	2020
Publisher:	ELIFE SCIENCES PUBLICATIONS LTD
Place of Publication:	CAMBRIDGE
ISSN:	2050-084X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Biology > Institute for Genetics
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LEUCINE-RICH REPEAT; NK-HOMEOBOX GENES; ORAL-ABORAL AXIS; TGF-BETA; PARAHOX GENES; SISTER GROUP; TRANSCRIPTION FACTORS; CONVERGENT EVOLUTION; MOLECULAR EVOLUTION; INSULATOR PROTEINS Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/32621