Universität zu Köln

Barthel, Romy, Fedorchenko, Oleg, Velmans, Tanja, Rosen, Natascha, Reinart, Nina, Florin, Alexandra, Herling, Marco, Hallek, Michael and Fingerle-Rowson, Guenter ORCID: 0000-0002-6621-7590 (2020). CD74 is dispensable for development of chronic lymphocytic leukemia inE mu-TCL1 transgenic mice. Leuk. Lymphoma, 61 (12). S. 2799 - 2811. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1029-2403

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Abstract

CD74 is a surface protein expressed on immune cells, which acts as receptor for the chemokine macrophage migration inhibitory factor (MIF). Signalingviathe MIF/CD74-axis has been reported to be important for the pathogenesis of chronic lymphocytic leukemia (CLL). We wanted to clarify the role of CD74 in MIF-induced signaling/leukemic development. In E mu-TCL1 transgenic mice, occurrence of the leukemic phenotype was associated with increased surface CD74 expression. E mu-TCL1(+/+)Cd74(-/-)mice showed similar kinetics and clinical features of CLL development as E mu-TCL1(+/+)mice. MIF stimulation of leukemic splenocytes led to AKT activation in a CD74-dependent manner. AKT activation was reduced in Cd74-deficient splenocytes in the presence of the oncogenic TCL1-transgene. Tumor cell apoptosis/proliferation were unaffected in E mu-TCL1(+/+)Cd74(-/-)mice. Our data suggest that the need for active CD74 signaling is overcome in the leukemic context of TCL1-driven CLL, and that CD74 may have a dispensable role for CLL pathogenesis in this model.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Barthel, Romy UNSPECIFIED UNSPECIFIED UNSPECIFIED Fedorchenko, Oleg UNSPECIFIED UNSPECIFIED UNSPECIFIED Velmans, Tanja UNSPECIFIED UNSPECIFIED UNSPECIFIED Rosen, Natascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Reinart, Nina UNSPECIFIED UNSPECIFIED UNSPECIFIED Florin, Alexandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Herling, Marco UNSPECIFIED UNSPECIFIED UNSPECIFIED Hallek, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED Fingerle-Rowson, Guenter UNSPECIFIED orcid.org/0000-0002-6621-7590 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-326456
DOI:	10.1080/10428194.2020.1791851
Journal or Publication Title:	Leuk. Lymphoma
Volume:	61
Number:	12
Page Range:	S. 2799 - 2811
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1029-2403
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language INVARIANT-CHAIN; CELL; TCL1; MIGRATION; EXPRESSION; DEFICIENT; PATTERN; LACKING; TUMORS; MOUSE Multiple languages Oncology; Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32645