Universität zu Köln

Duhalde, Lola, Lurienne, Lise, Wingen-Heimann, Sebastian M., Guillou, Lucien, Buffet, Renaud and Bandinelli, Pierre-Alain (2020). The economic burden of Clostridioides difficile infection in patients with hematological malignancies in the United States: A case-control study. Infect. Control Hosp. Epidemiol., 41 (7). S. 813 - 820. NEW YORK: CAMBRIDGE UNIV PRESS. ISSN 1559-6834

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Abstract

Objective: The primary study aim was to describe all direct healthcare costs associated with Clostridioides difficile infection (CDI), both in and out of the hospital, in patients with hematologic malignancies in the United States. Design: A retrospective analysis was conducted utilizing data from US databases of Truven Health Analytics. Patients: We analyzed health insurance claims between January 2014 and December 2017 of patients diagnosed with hematological cancer: acute myeloid leukemia (AML), acute lymphoblastic leukemia, Hodgkin's lymphoma, and non-Hodgkin's lymphoma (NHL). Methods: Patients with CDI after cancer diagnosis (CDI+, cases) were matched with patients without CDI reported (CDI-, controls). Matched cases and controls were compared to identify the CDI-associated costs in the 90 days following the onset of CDI. Results: We matched 622 CDI+ patients with 11,111 CDI- patients. NHL (41.7%) and AML (30.9%) were the predominant underlying diseases in the CDI+ groups. During study period, the average time in-hospital of CDI+ patients was 23.1 days longer than for CDI- patients (P < 2x10(-16)). Overall, CDI onset increased costs of care by an average of US$57,159 per patient (P = 6x10(-12)), mainly driven by hospital costs. Conclusions: This study confirms the significant economic burden associated with CDI in the United States, especially in patients with hematological malignancies. These findings highlight the need for prevention of CDI in this specific patient population.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Duhalde, Lola UNSPECIFIED UNSPECIFIED UNSPECIFIED Lurienne, Lise UNSPECIFIED UNSPECIFIED UNSPECIFIED Wingen-Heimann, Sebastian M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Guillou, Lucien UNSPECIFIED UNSPECIFIED UNSPECIFIED Buffet, Renaud UNSPECIFIED UNSPECIFIED UNSPECIFIED Bandinelli, Pierre-Alain UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-328586
DOI:	10.1017/ice.2020.153
Journal or Publication Title:	Infect. Control Hosp. Epidemiol.
Volume:	41
Number:	7
Page Range:	S. 813 - 820
Date:	2020
Publisher:	CAMBRIDGE UNIV PRESS
Place of Publication:	NEW YORK
ISSN:	1559-6834
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HOSPITALS; DIARRHEA; RISK Multiple languages Public, Environmental & Occupational Health; Infectious Diseases Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32858