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Wang, Jizong and Chai, Jijie (2020). Molecular actions of NLR immune receptors in plants and animals. Sci. China-Life Sci., 63 (9). S. 1303 - 1317. BEIJING: SCIENCE PRESS. ISSN 1869-1889

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Abstract

NLRs constitute intracellular immune receptors in both plants and animals. Direct or indirect ligand recognition results in formation of oligomeric NLR complexes to mediate immune signaling. Over the past 20 years, rapid progress has been made in our understanding of NLR signaling. Structural and biochemical studies provide insight into molecular basis of autoinhibition, ligand recognition, and resistosome/inflammasome formation of several NLRs. In this review, we summarize these studies focusing on the structural aspect of NLRs. We also discuss the analogies and differences between plant and animal NLRs in their mechanisms of action and how the available knowledge may shed light on the signaling mechanisms of other NLRs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wang, Jizong UNSPECIFIED UNSPECIFIED UNSPECIFIED Chai, Jijie UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-328977
DOI:	10.1007/s11427-019-1687-6
Journal or Publication Title:	Sci. China-Life Sci.
Volume:	63
Number:	9
Page Range:	S. 1303 - 1317
Date:	2020
Publisher:	SCIENCE PRESS
Place of Publication:	BEIJING
ISSN:	1869-1889
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NB-LRR PROTEIN; CELL-DEATH; RESISTANCE PROTEIN; STRUCTURAL BASIS; RUST RESISTANCE; CRYSTAL-STRUCTURE; GASDERMIN D; PATHOGEN PERCEPTION; DISEASE RESISTANCE; SELF-ASSOCIATION Multiple languages Biology Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/32897