Universität zu Köln

Pass, Thomas ORCID: 0000-0002-9915-7360, Assfalg, Marlene, Tolve, Marianna, Blaess, Sandra, Rothermel, Markus ORCID: 0000-0002-0929-993X, Wiesner, Rudolf J. and Ricke, Konrad M. (2020). The Impact of Mitochondrial Dysfunction on Dopaminergic Neurons in the Olfactory Bulb and Odor Detection. Mol. Neurobiol., 57 (9). S. 3646 - 3658. NEW YORK: SPRINGER. ISSN 1559-1182

Full text not available from this repository.

Abstract

Understanding non-motor symptoms of Parkinson's disease is important in order to unravel the underlying molecular mechanisms of the disease. Olfactory dysfunction is an early stage, non-motor symptom which occurs in 95% of Parkinson's disease patients. Mitochondrial dysfunction is a key feature in Parkinson's disease and importantly contributes to the selective loss of dopaminergic neurons thesubstantia nigra pars compacta. The olfactory bulb, the first olfactory processing station, also contains dopaminergic neurons, which modulate odor information and thereby enable odor detection as well as odor discrimination. MitoPark mice are a genetic model for Parkinson's disease with severe mitochondrial dysfunction, reproducing the differential vulnerability of dopaminergic neurons in the midbrain. These animals were used to investigate the impact of mitochondrial dysfunction on olfactory-related behavior and olfactory bulb dopaminergic neuron survival. Odor detection was severely impaired in MitoPark mice. Interestingly, only the small anaxonic dopaminergic subpopulation, which is continuously replenished by neurogenesis, was moderately reduced in number, much less compared with dopaminergic neurons in the midbrain. As a potential compensatory response, an enhanced mobilization of progenitor cells was found in the subventricular zone. These results reveal a high robustness of dopaminergic neurons located in the olfactory bulb towards mitochondrial impairment, in striking contrast to their midbrain counterparts.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Pass, Thomas UNSPECIFIED orcid.org/0000-0002-9915-7360 UNSPECIFIED Assfalg, Marlene UNSPECIFIED UNSPECIFIED UNSPECIFIED Tolve, Marianna UNSPECIFIED UNSPECIFIED UNSPECIFIED Blaess, Sandra UNSPECIFIED UNSPECIFIED UNSPECIFIED Rothermel, Markus UNSPECIFIED orcid.org/0000-0002-0929-993X UNSPECIFIED Wiesner, Rudolf J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ricke, Konrad M. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-329487
DOI:	10.1007/s12035-020-01947-w
Journal or Publication Title:	Mol. Neurobiol.
Volume:	57
Number:	9
Page Range:	S. 3646 - 3658
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1559-1182
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language NEURAL STEM-CELLS; PARKINSONS-DISEASE; PRESYNAPTIC INHIBITION; TRANSCRIPTION FACTOR; MICE; DISCRIMINATION; PAX6; ORGANIZATION; MODULATION; DEAFFERENTATION Multiple languages Neurosciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/32948