Espinosa-Cantu, Adriana, Cruz-Bonilla, Erika ORCID: 0000-0002-5668-2536, Noda-Garcia, Lianet and DeLuna, Alexander ORCID: 0000-0002-9236-2804 (2020). Multiple Forms of Multifunctional Proteins in Health and Disease. Front. Cell. Dev. Biol., 8. LAUSANNE: FRONTIERS MEDIA SA. ISSN 2296-634X

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Abstract

Protein science has moved from a focus on individual molecules to an integrated perspective in which proteins emerge as dynamic players with multiple functions, rather than monofunctional specialists. Annotation of the full functional repertoire of proteins has impacted the fields of biochemistry and genetics, and will continue to influence basic and applied science questions - from the genotype-to-phenotype problem, to our understanding of human pathologies and drug design. In this review, we address the phenomena of pleiotropy, multidomain proteins, promiscuity, and protein moonlighting, providing examples of multitasking biomolecules that underlie specific mechanisms of human disease. In doing so, we place in context different types of multifunctional proteins, highlighting useful attributes for their systematic definition and classification in future research directions.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Espinosa-Cantu, AdrianaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Cruz-Bonilla, ErikaUNSPECIFIEDorcid.org/0000-0002-5668-2536UNSPECIFIED
Noda-Garcia, LianetUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
DeLuna, AlexanderUNSPECIFIEDorcid.org/0000-0002-9236-2804UNSPECIFIED
URN: urn:nbn:de:hbz:38-330180
DOI: 10.3389/fcell.2020.00451
Journal or Publication Title: Front. Cell. Dev. Biol.
Volume: 8
Date: 2020
Publisher: FRONTIERS MEDIA SA
Place of Publication: LAUSANNE
ISSN: 2296-634X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
MOONLIGHTING PROTEINS; ENZYME PROMISCUITY; GENE-EXPRESSION; EVOLUTION; MITOCHONDRIAL; DATABASE; REVEALS; GAPDH; MULTITASKPROTDB; CRYSTALLINMultiple languages
Cell Biology; Developmental BiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33018

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