Flossdorf, Stefan, Schiwy-Bochat, Karl Heinz, Teifel, Daniela, Fries, Jochen W. U. and Rothschild, Markus A. (2020). Sudden death of a young adult with coronary artery vasculitis, coronary aneurysms, parvovirus B19 infection and Kawasaki disease. Forensic Sci. Med. Pathol., 16 (3). S. 498 - 504. TOTOWA: HUMANA PRESS INC. ISSN 1556-2891

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Abstract

We present a case of a 20-year-old man who suffered from Kawasaki disease (KD) associated with a florid parvovirus infection, and who died suddenly from thrombotic occlusion of the coronary arteries. The autopsy revealed several aneurysms of the coronary arteries, a chronic vasculitis and a myofibroblast proliferation leading to focal luminal narrowing. The inflammatory response as well as the detection of the viral particles by PCR in blood and in the lesional tissue demonstrated a possible cause by Parvovirus infection. The expression of endoglin on endothelial cells of neoangiogenesis indicates the involvement of the TGF-beta pathway, necessary for maintaining chronic inflammation. In addition, a possible connection between the intake of methylphenidate, arteritis and a possible pre-existing heart disease must be discussed. Furthermore, KD must also be considered as a cause of sudden death in the adult population.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Flossdorf, StefanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Schiwy-Bochat, Karl HeinzUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Teifel, DanielaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fries, Jochen W. U.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rothschild, Markus A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-330703
DOI: 10.1007/s12024-020-00263-y
Journal or Publication Title: Forensic Sci. Med. Pathol.
Volume: 16
Number: 3
Page Range: S. 498 - 504
Date: 2020
Publisher: HUMANA PRESS INC
Place of Publication: TOTOWA
ISSN: 1556-2891
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
LATE SEQUELAE; ENDOGLIN; VIRUS; BETA; EPIDEMIOLOGY; CHILDREN; FEATURES; BINDING; PROTEIN; ONSETMultiple languages
Medicine, Legal; PathologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33070

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