Flossdorf, Stefan, Schiwy-Bochat, Karl Heinz, Teifel, Daniela, Fries, Jochen W. U. and Rothschild, Markus A. (2020). Sudden death of a young adult with coronary artery vasculitis, coronary aneurysms, parvovirus B19 infection and Kawasaki disease. Forensic Sci. Med. Pathol., 16 (3). S. 498 - 504. TOTOWA: HUMANA PRESS INC. ISSN 1556-2891
Full text not available from this repository.Abstract
We present a case of a 20-year-old man who suffered from Kawasaki disease (KD) associated with a florid parvovirus infection, and who died suddenly from thrombotic occlusion of the coronary arteries. The autopsy revealed several aneurysms of the coronary arteries, a chronic vasculitis and a myofibroblast proliferation leading to focal luminal narrowing. The inflammatory response as well as the detection of the viral particles by PCR in blood and in the lesional tissue demonstrated a possible cause by Parvovirus infection. The expression of endoglin on endothelial cells of neoangiogenesis indicates the involvement of the TGF-beta pathway, necessary for maintaining chronic inflammation. In addition, a possible connection between the intake of methylphenidate, arteritis and a possible pre-existing heart disease must be discussed. Furthermore, KD must also be considered as a cause of sudden death in the adult population.
Item Type: | Journal Article | ||||||||||||||||||||||||
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URN: | urn:nbn:de:hbz:38-330703 | ||||||||||||||||||||||||
DOI: | 10.1007/s12024-020-00263-y | ||||||||||||||||||||||||
Journal or Publication Title: | Forensic Sci. Med. Pathol. | ||||||||||||||||||||||||
Volume: | 16 | ||||||||||||||||||||||||
Number: | 3 | ||||||||||||||||||||||||
Page Range: | S. 498 - 504 | ||||||||||||||||||||||||
Date: | 2020 | ||||||||||||||||||||||||
Publisher: | HUMANA PRESS INC | ||||||||||||||||||||||||
Place of Publication: | TOTOWA | ||||||||||||||||||||||||
ISSN: | 1556-2891 | ||||||||||||||||||||||||
Language: | English | ||||||||||||||||||||||||
Faculty: | Unspecified | ||||||||||||||||||||||||
Divisions: | Unspecified | ||||||||||||||||||||||||
Subjects: | no entry | ||||||||||||||||||||||||
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URI: | http://kups.ub.uni-koeln.de/id/eprint/33070 |
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