Universität zu Köln

Zhou, Chenghui ORCID: 0000-0003-1170-1761, Fan, Ningbo ORCID: 0000-0002-1622-6747, Liu, Fanyu, Fang, Nan, Plum, Patrick S. ORCID: 0000-0002-8165-4553, Thieme, Rene ORCID: 0000-0002-0537-3979, Gockel, Ines, Gromnitza, Sascha, Hillmer, Axel M., Chon, Seung-Hun ORCID: 0000-0002-8923-6428, Schloesser, Hans A., Bruns, Christiane J. and Zhao, Yue ORCID: 0000-0002-6790-3402 (2020). Linking Cancer Stem Cell Plasticity to Therapeutic Resistance-Mechanism and Novel Therapeutic Strategies in Esophageal Cancer. Cells, 9 (6). BASEL: MDPI. ISSN 2073-4409

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Abstract

Esophageal cancer (EC) is an aggressive form of cancer, including squamous cell carcinoma (ESCC) and adenocarcinoma (EAC) as two predominant histological subtypes. Accumulating evidence supports the existence of cancer stem cells (CSCs) able to initiate and maintain EAC or ESCC. In this review, we aim to collect the current evidence on CSCs in esophageal cancer, including the biomarkers/characterization strategies of CSCs, heterogeneity of CSCs, and the key signaling pathways (Wnt/beta-catenin, Notch, Hedgehog, YAP, JAK/STAT3) in modulating CSCs during esophageal cancer progression. Exploring the molecular mechanisms of therapy resistance in EC highlights DNA damage response (DDR), metabolic reprogramming, epithelial mesenchymal transition (EMT), and the role of the crosstalk of CSCs and their niche in the tumor progression. According to these molecular findings, potential therapeutic implications of targeting esophageal CSCs may provide novel strategies for the clinical management of esophageal cancer.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Zhou, Chenghui UNSPECIFIED orcid.org/0000-0003-1170-1761 UNSPECIFIED Fan, Ningbo UNSPECIFIED orcid.org/0000-0002-1622-6747 UNSPECIFIED Liu, Fanyu UNSPECIFIED UNSPECIFIED UNSPECIFIED Fang, Nan UNSPECIFIED UNSPECIFIED UNSPECIFIED Plum, Patrick S. UNSPECIFIED orcid.org/0000-0002-8165-4553 UNSPECIFIED Thieme, Rene UNSPECIFIED orcid.org/0000-0002-0537-3979 UNSPECIFIED Gockel, Ines UNSPECIFIED UNSPECIFIED UNSPECIFIED Gromnitza, Sascha UNSPECIFIED UNSPECIFIED UNSPECIFIED Hillmer, Axel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Chon, Seung-Hun UNSPECIFIED orcid.org/0000-0002-8923-6428 UNSPECIFIED Schloesser, Hans A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Bruns, Christiane J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Zhao, Yue UNSPECIFIED orcid.org/0000-0002-6790-3402 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-331259
DOI:	10.3390/cells9061481
Journal or Publication Title:	Cells
Volume:	9
Number:	6
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2073-4409
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR MICROENVIRONMENT; SIGNALING PATHWAY; NEOADJUVANT CHEMORADIOTHERAPY; ABCG2 EXPRESSION; PROGNOSTIC VALUE; DNA-DAMAGE; CARCINOMA; CHEMOTHERAPY; POPULATION Multiple languages Cell Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33125