Universität zu Köln

Gietzelt, Caroline, von Goscinski, Corinna, Lemke, Julia, Schaub, Friederike, Hermann, Manuel M., Dietlein, Thomas S., Cursiefen, Claus, Heindl, Ludwig M. and Enders, Philip (2020). Dynamics of structural reversal in Bruch's membrane opening-based morphometrics after glaucoma drainage device surgery. Graefes Arch. Clin. Exp. Ophthalmol., 258 (6). S. 1227 - 1237. NEW YORK: SPRINGER. ISSN 1435-702X

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Abstract

Purpose Structural reversal of disc cupping is a known phenomenon after trabeculectomy. The aim of this retrospective, longitudinal, cross-sectional analysis was to evaluate the postoperative dynamics of Bruch's membrane opening-based morphometrics of the optic nerve head following glaucoma drainage device surgery. Methods Forty-three eyes, treated by glaucoma drainage device surgery, were included in the study. Individual changes in the spectral domain optic coherence tomography (SD-OCT) parameters Bruch's membrane opening minimum rim width (BMO-MRW), Bruch's membrane opening minimum rim area (BMO-MRA) and peripapillary retinal nerve fiber layer (RNFL) thickness as well as mean defect in 30-2 perimetry were analyzed. Changes were correlated to postoperative intraocular pressure levels over time. Available follow-up visits were aggregated and grouped into a short-term follow-up (20 to 180 days after surgery), a midterm follow-up (181 to 360 days after surgery) and a long-term follow-up (more than 360 days after surgery). Results In short-term follow-up, BMO-MRW and BMO-MRA increased significantly (p <= 0.034). This increase correlated negatively with the intraocular pressure at the time of the follow-up (Pearson's rho = - 0.49; p = 0.039). From 6 months after surgery on, there was no statistically significant change in BMO-MRW and BMO-MRA (p >= 0.207). RNFL thickness and mean defect of 30-2 perimetry showed no significant changes after GDD implantation (p >= 0.189). Conclusions Lowering of intraocular pressure by glaucoma drainage device surgery leads to an increase of Bruch's membrane opening based parameters in the first 6 months after surgery. These changes have to be taken into account when evaluating patients' longitudinal follow-up after glaucoma drainage device implantation.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gietzelt, Caroline UNSPECIFIED UNSPECIFIED UNSPECIFIED von Goscinski, Corinna UNSPECIFIED UNSPECIFIED UNSPECIFIED Lemke, Julia UNSPECIFIED UNSPECIFIED UNSPECIFIED Schaub, Friederike UNSPECIFIED UNSPECIFIED UNSPECIFIED Hermann, Manuel M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Dietlein, Thomas S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Heindl, Ludwig M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Enders, Philip UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-332283
DOI:	10.1007/s00417-020-04621-y
Journal or Publication Title:	Graefes Arch. Clin. Exp. Ophthalmol.
Volume:	258
Number:	6
Page Range:	S. 1227 - 1237
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1435-702X
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language FIBER LAYER THICKNESS; OPTICAL COHERENCE TOMOGRAPHY; MINIMUM RIM WIDTH; INTRAOCULAR-PRESSURE; NERVE HEAD; IMPLANT; TRABECULECTOMY; TOPOGRAPHY Multiple languages Ophthalmology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33228