Universität zu Köln

Feni, Lucia, Juetten, Linda, Parente, Sara, Piarulli, Umberto, Neundorf, Ines ORCID: 0000-0001-6450-3991 and Diaz, Dolores ORCID: 0000-0002-2406-4952 (2020). Cell-penetrating peptides containing 2,5-diketopiperazine (DKP) scaffolds as shuttles for anti-cancer drugs: conformational studies and biological activity. Chem. Commun., 56 (42). S. 5685 - 5689. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1364-548X

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Abstract

A series of linear and cyclic peptidomimetics composed of a cell-penetrating peptide and a non-natural, bifunctional 2,5-diketopiperazine scaffold is reported. Conformational studies revealed well-defined helical structures in micellar medium for linear structures, while cyclic peptidomimetics were more flexible. Biological investigations showed higher membrane-activity of cyclic derivatives allowing their use as shuttles for anti-cancer drugs.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Feni, Lucia UNSPECIFIED UNSPECIFIED UNSPECIFIED Juetten, Linda UNSPECIFIED UNSPECIFIED UNSPECIFIED Parente, Sara UNSPECIFIED UNSPECIFIED UNSPECIFIED Piarulli, Umberto UNSPECIFIED UNSPECIFIED UNSPECIFIED Neundorf, Ines UNSPECIFIED orcid.org/0000-0001-6450-3991 UNSPECIFIED Diaz, Dolores UNSPECIFIED orcid.org/0000-0002-2406-4952 UNSPECIFIED
URN:	urn:nbn:de:hbz:38-332938
DOI:	10.1039/d0cc01490g
Journal or Publication Title:	Chem. Commun.
Volume:	56
Number:	42
Page Range:	S. 5685 - 5689
Date:	2020
Publisher:	ROYAL SOC CHEMISTRY
Place of Publication:	CAMBRIDGE
ISSN:	1364-548X
Language:	English
Faculty:	Faculty of Mathematics and Natural Sciences
Divisions:	Faculty of Mathematics and Natural Sciences > Department of Chemistry > Institute of Biochemistry
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CYCLIC-PEPTIDES Multiple languages Chemistry, Multidisciplinary Multiple languages
Refereed:	Yes
URI:	http://kups.ub.uni-koeln.de/id/eprint/33293