Feni, Lucia, Juetten, Linda, Parente, Sara, Piarulli, Umberto, Neundorf, Ines and Diaz, Dolores ORCID: 0000-0002-2406-4952 (2020). Cell-penetrating peptides containing 2,5-diketopiperazine (DKP) scaffolds as shuttles for anti-cancer drugs: conformational studies and biological activity. Chem. Commun., 56 (42). S. 5685 - 5689. CAMBRIDGE: ROYAL SOC CHEMISTRY. ISSN 1364-548X

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Abstract

A series of linear and cyclic peptidomimetics composed of a cell-penetrating peptide and a non-natural, bifunctional 2,5-diketopiperazine scaffold is reported. Conformational studies revealed well-defined helical structures in micellar medium for linear structures, while cyclic peptidomimetics were more flexible. Biological investigations showed higher membrane-activity of cyclic derivatives allowing their use as shuttles for anti-cancer drugs.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Feni, LuciaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Juetten, LindaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parente, SaraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Piarulli, UmbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Neundorf, InesUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Diaz, DoloresUNSPECIFIEDorcid.org/0000-0002-2406-4952UNSPECIFIED
URN: urn:nbn:de:hbz:38-332938
DOI: 10.1039/d0cc01490g
Journal or Publication Title: Chem. Commun.
Volume: 56
Number: 42
Page Range: S. 5685 - 5689
Date: 2020
Publisher: ROYAL SOC CHEMISTRY
Place of Publication: CAMBRIDGE
ISSN: 1364-548X
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
CYCLIC-PEPTIDESMultiple languages
Chemistry, MultidisciplinaryMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33293

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