Universität zu Köln

Schobert, Isabel Theresa, Savic, Lynn Jeanette ORCID: 0000-0003-2115-6728, Chapiro, Julius, Bousabarah, Khaled, Chen, Evan, Laage-Gaupp, Fabian, Tefera, Jonathan, Nezami, Nariman, Lin, MingDe, Pollak, Jeffrey and Schlachter, Todd (2020). Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios as predictors of tumor response in hepatocellular carcinoma after DEB-TACE. Eur. Radiol., 30 (10). S. 5663 - 5674. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives To investigate the predictive value of quantifiable imaging and inflammatory biomarkers in patients with hepatocellular carcinoma (HCC) for the clinical outcome after drug-eluting bead transarterial chemoembolization (DEB-TACE) measured as volumetric tumor response and progression-free survival (PFS). Methods This retrospective study included 46 patients with treatment-naive HCC who received DEB-TACE. Laboratory work-up prior to treatment included complete and differential blood count, liver function, and alpha-fetoprotein levels. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were correlated with radiomic features extracted from pretreatment contrast-enhanced magnetic resonance imaging (MRI) and with tumor response according to quantitative European Association for the Study of the Liver (qEASL) criteria and progression-free survival (PFS) after DEB-TACE. Radiomic features included single nodular tumor growth measured as sphericity, dynamic contrast uptake behavior, arterial hyperenhancement, and homogeneity of contrast uptake. Statistics included univariate and multivariate linear regression, Cox regression, and Kaplan-Meier analysis. Results Accounting for laboratory and clinical parameters, high baseline NLR and PLR were predictive of poorer tumor response (p = 0.014 and p = 0.004) and shorter PFS (p = 0.002 and p < 0.001). When compared to baseline imaging, high NLR and PLR correlated with non-spherical tumor growth (p = 0.001 and p < 0.001). Conclusions This study establishes the prognostic value of quantitative inflammatory biomarkers associated with aggressive non-spherical tumor growth and predictive of poorer tumor response and shorter PFS after DEB-TACE.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Schobert, Isabel Theresa UNSPECIFIED UNSPECIFIED UNSPECIFIED Savic, Lynn Jeanette UNSPECIFIED orcid.org/0000-0003-2115-6728 UNSPECIFIED Chapiro, Julius UNSPECIFIED UNSPECIFIED UNSPECIFIED Bousabarah, Khaled UNSPECIFIED UNSPECIFIED UNSPECIFIED Chen, Evan UNSPECIFIED UNSPECIFIED UNSPECIFIED Laage-Gaupp, Fabian UNSPECIFIED UNSPECIFIED UNSPECIFIED Tefera, Jonathan UNSPECIFIED UNSPECIFIED UNSPECIFIED Nezami, Nariman UNSPECIFIED UNSPECIFIED UNSPECIFIED Lin, MingDe UNSPECIFIED UNSPECIFIED UNSPECIFIED Pollak, Jeffrey UNSPECIFIED UNSPECIFIED UNSPECIFIED Schlachter, Todd UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-333454
DOI:	10.1007/s00330-020-06931-5
Journal or Publication Title:	Eur. Radiol.
Volume:	30
Number:	10
Page Range:	S. 5663 - 5674
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language DRUG-ELUTING BEADS; TRANSARTERIAL CHEMOEMBOLIZATION; SYSTEMIC INFLAMMATION; PD-L1 EXPRESSION; CANCER; SURVIVAL; IMMUNOTHERAPY; CELLS; RECURRENCE; MANAGEMENT Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33345