Universität zu Köln

Gerisch, Birgit, Tharyan, Rebecca George, Mak, Jennifer, Denzel, Sarah, I, Popkes-van Oepen, Till, Henn, Nadine and Antebi, Adam (2020). HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence. Dev. Cell, 53 (3). S. 316 - 335. CAMBRIDGE: CELL PRESS. ISSN 1878-1551

Full text not available from this repository.

Abstract

All animals have evolved the ability to survive nutrient deprivation, and nutrient signaling pathways are conserved modulators of health and disease. In C. elegans, late-larval starvation provokes the adult reproductive diapause (ARD), a long-lived quiescent state that enables survival for months without food, yet underlying molecular mechanisms remain unknown. Here, we show that ARD is distinct from other forms of diapause, showing little requirement for canonical longevity pathways, autophagy, and fat metabolism. Instead it requires the HLH-30/TFEB transcription factor to promote the morphological and physiological remodeling involved in ARD entry, survival, and recovery, suggesting that HLH-30 is a master regulator of reproductive quiescence. HLH-30 transcriptome and genetic analyses reveal that Max-like HLH factors, AMP-kinase, mTOR, protein synthesis, and mitochondrial fusion are target processes that promote ARD longevity. ARD thus rewires metabolism to ensure long-term survival and may illuminate similar mechanisms acting in stem cell quiescence and long-term fasting.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Gerisch, Birgit UNSPECIFIED UNSPECIFIED UNSPECIFIED Tharyan, Rebecca George UNSPECIFIED UNSPECIFIED UNSPECIFIED Mak, Jennifer UNSPECIFIED UNSPECIFIED UNSPECIFIED Denzel, Sarah, I UNSPECIFIED UNSPECIFIED UNSPECIFIED Popkes-van Oepen, Till UNSPECIFIED UNSPECIFIED UNSPECIFIED Henn, Nadine UNSPECIFIED UNSPECIFIED UNSPECIFIED Antebi, Adam UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334436
DOI:	10.1016/j.devcel.2020.03.014
Journal or Publication Title:	Dev. Cell
Volume:	53
Number:	3
Page Range:	S. 316 - 335
Date:	2020
Publisher:	CELL PRESS
Place of Publication:	CAMBRIDGE
ISSN:	1878-1551
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language EXTENDS LIFE-SPAN; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; MOLECULAR-MECHANISMS; STEM-CELLS; AUTOPHAGY; INHIBITION; LONGEVITY; GENE; TFEB Multiple languages Cell Biology; Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33443