Universität zu Köln

Salabarria, Ann-Charlott ORCID: 0000-0001-6829-2001, Koch, Manuel, Schoenberg, Alfrun, Zinser, Elisabeth, Hos, Deniz, Hamdorf, Matthias ORCID: 0000-0003-3744-4548, Imhof, Thomas, Braun, Gabriele, Cursiefen, Claus and Bock, Felix (2020). Topical VEGF-C/D Inhibition Prevents Lymphatic Vessel Ingrowth into Cornea but Does Not Improve Corneal Graft Survival. J. Clin. Med., 9 (5). BASEL: MDPI. ISSN 2077-0383

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Abstract

Vascular endothelial growth factor-C/D (VEGF-C/D) regulates lymphangiogenesis. Ingrowth of lymphatic vessels is negatively associated with corneal transplantation success. In this study, we therefore analyzed the effect local blockade of VEGF-C/D has on inflamed corneas. We used the murine model of suture-induced neovascularization and subsequent high-risk corneal transplantation. Mice were treated with a VEGF-C/D trap prior to transplantation. Topical inhibition of VEGF-C/D significantly reduced lymphatic vessel ingrowth, but increased Macrophage numbers in the cornea. Furthermore, corneal transplantation success was not improved by the topical application of the compound. This study demonstrates that local VEGF-C/D inhibition is insufficient to increases corneal transplantation success, likely due to interaction with immune cells.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Salabarria, Ann-Charlott UNSPECIFIED orcid.org/0000-0001-6829-2001 UNSPECIFIED Koch, Manuel UNSPECIFIED UNSPECIFIED UNSPECIFIED Schoenberg, Alfrun UNSPECIFIED UNSPECIFIED UNSPECIFIED Zinser, Elisabeth UNSPECIFIED UNSPECIFIED UNSPECIFIED Hos, Deniz UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamdorf, Matthias UNSPECIFIED orcid.org/0000-0003-3744-4548 UNSPECIFIED Imhof, Thomas UNSPECIFIED UNSPECIFIED UNSPECIFIED Braun, Gabriele UNSPECIFIED UNSPECIFIED UNSPECIFIED Cursiefen, Claus UNSPECIFIED UNSPECIFIED UNSPECIFIED Bock, Felix UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-334896
DOI:	10.3390/jcm9051270
Journal or Publication Title:	J. Clin. Med.
Volume:	9
Number:	5
Date:	2020
Publisher:	MDPI
Place of Publication:	BASEL
ISSN:	2077-0383
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language LYMPHANGIOGENESIS; TRANSPLANTATION; NEOVASCULARIZATION; REJECTION; BLOCKADE; HEMANGIOGENESIS; ANGIOGENESIS; INFLAMMATION; SUPPRESSION; THERAPY Multiple languages Medicine, General & Internal Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33489