Universität zu Köln

Herb, Marc ORCID: 0000-0002-7533-0288, Gluschko, Alexander and Schramm, Michael (2020). LC3-associated phagocytosis - The highway to hell for phagocytosed microbes. Semin. Cell Dev. Biol., 101. S. 68 - 77. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. ISSN 1096-3634

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Abstract

Phagocytes ingest, kill and degrade invading microbes in a process called phagocytosis. LC3-associated phagocytosis (LAP) combines the molecular machinery of phagocytosis with that of autophagy, the cellular pathway for ingestion of cytoplasmic components, resulting in the eponymous association of 'microtubule-associated proteins 1 A/1B light chain 3' (LC3) with the phagosomal membrane. The LC3-decorated phagosomes, or LAPosomes, show enhanced fusion with lysosomes resulting in enhanced killing and degradation of contained pathogens. Thus, LAP is a particularly microbicidal pathway. In this review, we discuss the molecular mechanisms involved in induction and execution of LAP and its crucial role in antimicrobial immunity against bacteria, fungi and parasites. As LAP has only recently been defined, we also point out the key open questions that remain to be answered.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Herb, Marc UNSPECIFIED orcid.org/0000-0002-7533-0288 UNSPECIFIED Gluschko, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Schramm, Michael UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-335261
DOI:	10.1016/j.semcdb.2019.04.016
Journal or Publication Title:	Semin. Cell Dev. Biol.
Volume:	101
Page Range:	S. 68 - 77
Date:	2020
Publisher:	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Place of Publication:	LONDON
ISSN:	1096-3634
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language CHAIN 3 PROTEIN; LISTERIA-MONOCYTOGENES; AUTOPHAGY PROTEINS; NONCANONICAL AUTOPHAGY; LC3 RECRUITMENT; HOST; PHAGOSOMES; COMPLEX; RUBICON; MACROPHAGES Multiple languages Cell Biology; Developmental Biology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33526