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Cirillo, Melita and Borchmann, Sven (2020). An update on disease biomarkers for Hodgkin lymphoma. Expert Rev. Hematol., 13 (5). S. 481 - 489. ABINGDON: TAYLOR & FRANCIS LTD. ISSN 1747-4094

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Abstract

Introduction: Hodgkin Lymphoma (HL) carries an overall excellent prognosis for young patients treated with multimodal therapy. Predicting an individual patient's prognosis is currently heavily dependent on imaging modalities such as Positron Emission Tomography (PET). Areas covered: Potential biomarkers from serum, tissue, circulating nucleic acids and non-tumor derived cells have all been reported to be of prognostic relevance in HL. We review a range of these biomarkers and discuss the integration of new biomarkers into individualized patient care. Expert opinion: Better prognostic markers are needed to predict an individuals response to HL therapy. Interim PET-scan improves the ability to predict long-term treatment responders. However, it is our opinion that supplementation of PET results with additional biomarkers (including circulating tumor DNA, protein biomarkers, tissue genotyping and metabolic tumor volume) are likely to improve risk stratification for future patients with HL.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Cirillo, Melita UNSPECIFIED UNSPECIFIED UNSPECIFIED Borchmann, Sven UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-337571
DOI:	10.1080/17474086.2020.1746183
Journal or Publication Title:	Expert Rev. Hematol.
Volume:	13
Number:	5
Page Range:	S. 481 - 489
Date:	2020
Publisher:	TAYLOR & FRANCIS LTD
Place of Publication:	ABINGDON
ISSN:	1747-4094
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language POSITRON-EMISSION-TOMOGRAPHY; RESPONSE-ADAPTED THERAPY; METABOLIC TUMOR VOLUME; INTERNATIONAL PROGNOSTIC SCORE; STEM-CELL TRANSPLANTATION; REED-STERNBERG CELLS; FREE CIRCULATING DNA; SERUM TARC LEVELS; BARR-VIRUS-DNA; INTERGROUP TRIAL Multiple languages Hematology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33757