Universität zu Köln

Lewis, Philip ORCID: 0000-0002-5881-6032, Hellmich, Martin, Fritschi, Lin ORCID: 0000-0002-7692-3560, Tikellis, Gabriella, Morfeld, Peter, Gross, J. Valerie, Fostere, Russell G., Paltiel, Ora, Klebanoff, Mark A., Golding, Jean, Olsen, Sjurdur, Magnus, Per, Ponsonby, Anne-Louise ORCID: 0000-0002-6581-3657, Linet, Martha S., Ward, Mary H., Caporaso, Neil, Dwyer, Terence and Erren, Thomas C. (2020). Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C). Chronobiol. Int., 37 (7). S. 1034 - 1048. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1525-6073

Full text not available from this repository.

Abstract

Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight as determined by time-of-year and location) and childhood cancer risk. We use pooled data on 182,856 mothers and babies from prospective birth cohorts in six countries (Australia, Denmark, Israel, Norway, UK, USA) within the International Childhood Cancer Cohort Consortium (I4C). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In line with predicted differential dose-responses, restricted cubic splines indicate a potential non-linear, non-monotonic relationship between perinatal mean daily photoperiod (0-24 h) and childhood cancer risk. In a restricted analysis of 154,121 individuals who experienced third trimester photoperiods exclusively within the 8-16-h range, the relative risk of developing childhood cancer decreased by 9% with every hour increase in third trimester mean daily photoperiod [HR: 0.91 (95%CIs: 0.84-0.99)]. In conclusion, in this first study of perinatal photoperiod and childhood cancer, we detected an inverse [protective] linear association between third trimester mean daily photoperiod and childhood cancer risk in the 8-16-h set of the total study population. Limited statistical power impeded the investigation of risks with individuals exposed to more extreme photoperiods. Future studies are needed to confirm differential photoperiod-associated risks and further investigations into the hypothesized circadian imprinting mechanism are warranted.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Lewis, Philip UNSPECIFIED orcid.org/0000-0002-5881-6032 UNSPECIFIED Hellmich, Martin UNSPECIFIED UNSPECIFIED UNSPECIFIED Fritschi, Lin UNSPECIFIED orcid.org/0000-0002-7692-3560 UNSPECIFIED Tikellis, Gabriella UNSPECIFIED UNSPECIFIED UNSPECIFIED Morfeld, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED Gross, J. Valerie UNSPECIFIED UNSPECIFIED UNSPECIFIED Fostere, Russell G. UNSPECIFIED UNSPECIFIED UNSPECIFIED Paltiel, Ora UNSPECIFIED UNSPECIFIED UNSPECIFIED Klebanoff, Mark A. UNSPECIFIED UNSPECIFIED UNSPECIFIED Golding, Jean UNSPECIFIED UNSPECIFIED UNSPECIFIED Olsen, Sjurdur UNSPECIFIED UNSPECIFIED UNSPECIFIED Magnus, Per UNSPECIFIED UNSPECIFIED UNSPECIFIED Ponsonby, Anne-Louise UNSPECIFIED orcid.org/0000-0002-6581-3657 UNSPECIFIED Linet, Martha S. UNSPECIFIED UNSPECIFIED UNSPECIFIED Ward, Mary H. UNSPECIFIED UNSPECIFIED UNSPECIFIED Caporaso, Neil UNSPECIFIED UNSPECIFIED UNSPECIFIED Dwyer, Terence UNSPECIFIED UNSPECIFIED UNSPECIFIED Erren, Thomas C. UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-337715
DOI:	10.1080/07420528.2020.1740724
Journal or Publication Title:	Chronobiol. Int.
Volume:	37
Number:	7
Page Range:	S. 1034 - 1048
Date:	2020
Publisher:	TAYLOR & FRANCIS INC
Place of Publication:	PHILADELPHIA
ISSN:	1525-6073
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language ACUTE LYMPHOBLASTIC-LEUKEMIA; CIRCADIAN DISRUPTION; SEASONAL-VARIATION; NORTHERN ENGLAND; RISK-FACTORS; BIRTH; LIGHT; DIAGNOSIS; CHILDREN; CLOCKS Multiple languages Biology; Physiology Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/33771