Lewis, Philip ORCID: 0000-0002-5881-6032, Hellmich, Martin, Fritschi, Lin ORCID: 0000-0002-7692-3560, Tikellis, Gabriella, Morfeld, Peter, Gross, J. Valerie, Fostere, Russell G., Paltiel, Ora, Klebanoff, Mark A., Golding, Jean, Olsen, Sjurdur, Magnus, Per, Ponsonby, Anne-Louise ORCID: 0000-0002-6581-3657, Linet, Martha S., Ward, Mary H., Caporaso, Neil, Dwyer, Terence and Erren, Thomas C. (2020). Perinatal photoperiod and childhood cancer: pooled results from 182,856 individuals in the international childhood cancer cohort consortium (I4C). Chronobiol. Int., 37 (7). S. 1034 - 1048. PHILADELPHIA: TAYLOR & FRANCIS INC. ISSN 1525-6073

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Abstract

Experimental evidence suggests that perinatal light imprinting of circadian clocks and systems may affect downstream physiology and cancer risk in later life. For humans, the predominant circadian stimulus is the daily light-dark cycle. Herein, we explore associations between perinatal photoperiod characteristics (photoperiod: duration of daylight as determined by time-of-year and location) and childhood cancer risk. We use pooled data on 182,856 mothers and babies from prospective birth cohorts in six countries (Australia, Denmark, Israel, Norway, UK, USA) within the International Childhood Cancer Cohort Consortium (I4C). Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). In line with predicted differential dose-responses, restricted cubic splines indicate a potential non-linear, non-monotonic relationship between perinatal mean daily photoperiod (0-24 h) and childhood cancer risk. In a restricted analysis of 154,121 individuals who experienced third trimester photoperiods exclusively within the 8-16-h range, the relative risk of developing childhood cancer decreased by 9% with every hour increase in third trimester mean daily photoperiod [HR: 0.91 (95%CIs: 0.84-0.99)]. In conclusion, in this first study of perinatal photoperiod and childhood cancer, we detected an inverse [protective] linear association between third trimester mean daily photoperiod and childhood cancer risk in the 8-16-h set of the total study population. Limited statistical power impeded the investigation of risks with individuals exposed to more extreme photoperiods. Future studies are needed to confirm differential photoperiod-associated risks and further investigations into the hypothesized circadian imprinting mechanism are warranted.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Lewis, PhilipUNSPECIFIEDorcid.org/0000-0002-5881-6032UNSPECIFIED
Hellmich, MartinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fritschi, LinUNSPECIFIEDorcid.org/0000-0002-7692-3560UNSPECIFIED
Tikellis, GabriellaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morfeld, PeterUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gross, J. ValerieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fostere, Russell G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Paltiel, OraUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Klebanoff, Mark A.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Golding, JeanUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Olsen, SjurdurUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Magnus, PerUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ponsonby, Anne-LouiseUNSPECIFIEDorcid.org/0000-0002-6581-3657UNSPECIFIED
Linet, Martha S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ward, Mary H.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Caporaso, NeilUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Dwyer, TerenceUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Erren, Thomas C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-337715
DOI: 10.1080/07420528.2020.1740724
Journal or Publication Title: Chronobiol. Int.
Volume: 37
Number: 7
Page Range: S. 1034 - 1048
Date: 2020
Publisher: TAYLOR & FRANCIS INC
Place of Publication: PHILADELPHIA
ISSN: 1525-6073
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ACUTE LYMPHOBLASTIC-LEUKEMIA; CIRCADIAN DISRUPTION; SEASONAL-VARIATION; NORTHERN ENGLAND; RISK-FACTORS; BIRTH; LIGHT; DIAGNOSIS; CHILDREN; CLOCKSMultiple languages
Biology; PhysiologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33771

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