Gillessena, Silke, Attard, Gerhardt, Beer, Tomasz M., Beltran, Himisha, Bjartell, Anders, Bossi, Alberto, Briganti, Alberto, Bristow, Rob G., Chi, Kim N., Clarke, Noel, Davis, Ian D., de Bono, Johann, Drake, Charles G., Duran, Ignacio, Eeles, Ros, Efstathiou, Eleni, Evans, Christopher P., Fanti, Stefano, Feng, Felix Y., Fizazi, Karim, Frydenberg, Mark, Gleave, Martin ORCID: 0000-0003-4235-0167, Halabi, Susan ORCID: 0000-0003-4135-2777, Heidenreich, Axel, Heinrich, Daniel, Higano, Celestia (Tia) S., Hofman, Michael S., Hussain, Maha, James, Nicolas, Kanesvaran, Ravindran, Kantoff, Philip, Khauli, Raja B., Leibowitz, Raya, Logothetis, Chris, Maluf, Fernando, Millman, Robin, Morgans, Alicia K., Morris, Michael J., Mottet, Nicolas, Mrabti, Hind, Murphy, Declan G., Murthy, Vedang, Oh, William K., Ost, Piet, OSullivan, Joe M., Padhani, Anwar R., Parker, Chris, Poon, Darren M. C., Pritchard, Colin C., Reiter, Robert E., Roach, Mack, Rubin, Mark, Ryan, Charles J., Saad, Fred, Sade, Juan Pablo, Sartor, Oliver, Scher, Howard, I, Shore, Neal, Small, Eric, Smith, Matthew, Soule, Howard, Sternberg, Cora N., Steuber, Thomas, Suzuki, Hiroyoshi, Sweeneyh, Christopher, Sydes, Matthew R., Taplinh, Mary-Ellen, Tombal, Bertrand, Turkeri, Levent, van Oort, Inge ORCID: 0000-0002-8002-1869, Zapatero, Almudena and Omlind, Aurelius (2020). Management of Patients with Advanced Prostate Cancer: Report of the Advanced Prostate Cancer Consensus Conference 2019. Eur. Urol., 77 (4). S. 508 - 548. AMSTERDAM: ELSEVIER. ISSN 1873-7560

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Abstract

Background: Innovations in treatments, imaging, and molecular characterisation in advanced prostate cancer have improved outcomes, but there are still many aspects of management that lack high-level evidence to inform clinical practice. The Advanced Prostate Cancer Consensus Conference (APCCC) 2019 addressed some of these topics to supplement guidelines that are based on level 1 evidence. Objective: To present the results from the APCCC 2019. Design, setting, and participants: Similar to prior conferences, experts identified 10 important areas of controversy regarding the management of advanced prostate cancer: locally advanced disease, biochemical recurrence after local therapy, treating the primary tumour in the metastatic setting, metastatic hormone-sensitive/naive prostate cancer, nonmetastatic castration-resistant prostate cancer, metastatic castration-resistant prostate cancer, bone health and bone metastases, molecular characterisation of tissue and blood, inter- and intrapatient heterogeneity, and adverse effects of hormonal therapy and their management. A panel of 72 international prostate cancer experts developed the programme and the consensus questions. Outcome measurements and statistical analysis: The panel voted publicly but anonymously on 123 predefined questions, which were developed by both voting and nonvoting panel members prior to the conference following a modified Delphi process. Results and limitations: Panellists voted based on their opinions rather than a standard literature review or formal meta-analysis. The answer options for the consensus questions had varying degrees of support by the panel, as reflected in this article and the detailed voting results reported in the Supplementary material. Conclusions: These voting results from a panel of prostate cancer experts can help clinicians and patients navigate controversial areas of advanced prostate management for which high-level evidence is sparse. However, diagnostic and treatment decisions should always be individualised based on patient-specific factors, such as disease extent and location, prior lines of therapy, comorbidities, and treatment preferences, together with current and emerging clinical evidence and logistic and economic constraints. Clinical trial enrolment for men with advanced prostate cancer should be strongly encouraged. Importantly, APCCC 2019 once again identified important questions that merit assessment in specifically designed trials. Patient summary: The Advanced Prostate Cancer Consensus Conference provides a forum to discuss and debate current diagnostic and treatment options for patients with advanced prostate cancer. The conference, which has been held three times since 2015, aims to share the knowledge of world experts in prostate cancer management with health care providers worldwide. At the end of the conference, an expert panel discusses and votes on predefined consensus questions that target the most clinically relevant areas of advanced prostate cancer treatment. The results of the voting provide a practical guide to help clinicians discuss therapeutic options with patients as part of shared and multidisciplinary decision making. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of European Association of Urology.

Item Type: Journal Article
Creators:
CreatorsEmailORCIDORCID Put Code
Gillessena, SilkeUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Attard, GerhardtUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beer, Tomasz M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Beltran, HimishaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bjartell, AndersUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bossi, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Briganti, AlbertoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Bristow, Rob G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Chi, Kim N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Clarke, NoelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Davis, Ian D.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
de Bono, JohannUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Drake, Charles G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Duran, IgnacioUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Eeles, RosUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Efstathiou, EleniUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Evans, Christopher P.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fanti, StefanoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Feng, Felix Y.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Fizazi, KarimUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Frydenberg, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Gleave, MartinUNSPECIFIEDorcid.org/0000-0003-4235-0167UNSPECIFIED
Halabi, SusanUNSPECIFIEDorcid.org/0000-0003-4135-2777UNSPECIFIED
Heidenreich, AxelUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Heinrich, DanielUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Higano, Celestia (Tia) S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hofman, Michael S.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Hussain, MahaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
James, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kanesvaran, RavindranUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Kantoff, PhilipUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Khauli, Raja B.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Leibowitz, RayaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Logothetis, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Maluf, FernandoUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Millman, RobinUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morgans, Alicia K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Morris, Michael J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mottet, NicolasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Mrabti, HindUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murphy, Declan G.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Murthy, VedangUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Oh, William K.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ost, PietUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
OSullivan, Joe M.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Padhani, Anwar R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Parker, ChrisUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Poon, Darren M. C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Pritchard, Colin C.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Reiter, Robert E.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Roach, MackUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Rubin, MarkUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Ryan, Charles J.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Saad, FredUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sade, Juan PabloUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sartor, OliverUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Scher, Howard, IUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Shore, NealUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Small, EricUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Smith, MatthewUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Soule, HowardUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sternberg, Cora N.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Steuber, ThomasUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Suzuki, HiroyoshiUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sweeneyh, ChristopherUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Sydes, Matthew R.UNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Taplinh, Mary-EllenUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Tombal, BertrandUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Turkeri, LeventUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
van Oort, IngeUNSPECIFIEDorcid.org/0000-0002-8002-1869UNSPECIFIED
Zapatero, AlmudenaUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Omlind, AureliusUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
URN: urn:nbn:de:hbz:38-339620
DOI: 10.1016/j.eururo.2020.01.012
Journal or Publication Title: Eur. Urol.
Volume: 77
Number: 4
Page Range: S. 508 - 548
Date: 2020
Publisher: ELSEVIER
Place of Publication: AMSTERDAM
ISSN: 1873-7560
Language: English
Faculty: Unspecified
Divisions: Unspecified
Subjects: no entry
Uncontrolled Keywords:
KeywordsLanguage
ANDROGEN-DEPRIVATION THERAPY; SALVAGE RADIATION-THERAPY; LYMPH-NODE DISSECTION; QUALITY-OF-LIFE; HOT FLASHES; RADICAL PROSTATECTOMY; CLINICAL-TRIALS; FREE SURVIVAL; PHASE-II; TESTOSTERONE MEASUREMENTSMultiple languages
Urology & NephrologyMultiple languages
URI: http://kups.ub.uni-koeln.de/id/eprint/33962

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