Universität zu Köln

Rudolph, Madhuri M., Baur, Alexander D. J., Haas, Matthias, Cash, Hannes, Miller, Kurt, Mahjoub, Samy ORCID: 0000-0001-5151-1853, Hartenstein, Alexander, Kaufmann, David, Rotzinger, Roman, Lee, Chau Hung, Asbach, Patrick, Hamm, Bernd and Penzkofer, Tobias (2020). Validation of the PI-RADS language: predictive values of PI-RADS lexicon descriptors for detection of prostate cancer. Eur. Radiol., 30 (8). S. 4262 - 4272. NEW YORK: SPRINGER. ISSN 1432-1084

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Abstract

Objectives To assess the discriminatory power of lexicon terms used in PI-RADS version 2 to describe MRI features of prostate lesions. Methods Four hundred fifty-four patients were included in this retrospective, institutional review board-approved study. Patients received multiparametric (mp) MRI and subsequent prostate biopsy including MRI/transrectal ultrasound fusion biopsy and 10-core systematic biopsy. PI-RADS lexicon terms describing lesion characteristics on mpMRI were assigned to lesions by experienced readers. Positive and negative predictive values (PPV, NPV) of each lexicon term were assessed using biopsy results as a reference standard. Results From a total of 501 lesions, clinically significant prostate cancer (csPCa) was present in 175 lesions (34.9%). Terms related to findings of restricted diffusion showed PPVs of up to 52.0%/43.9% and NPV of up to 91.8%/89.7% (peripheral zone or PZ/transition zone or TZ). T2-weighted imaging (T2W)-related terms showed a wide range of predictive values. For PZ lesions, high PPVs were found for markedly hypointense, lenticular, lobulated, and spiculated (PPVs between 67.2 and 56.7%). For TZ lesions, high PPVs were found for water-drop-shaped and erased charcoal sign (78.6% and 61.0%). The terms encapsulated, organized chaos, and linear showed to be good predictors for benignity with distinctively low PPVs between 5.4 and 6.9%. Most T2WI-related terms showed improved predictive values for TZ lesions when combined with DWI-related findings. Conclusions Lexicon terms with high discriminatory power were identified (e.g., markedly hypointense, water-drop-shaped, organized chaos). DWI-related terms can be useful for excluding TZ cancer. Combining T2WI- with DWI findings in TZ lesions markedly improved predictive values.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Rudolph, Madhuri M. UNSPECIFIED UNSPECIFIED UNSPECIFIED Baur, Alexander D. J. UNSPECIFIED UNSPECIFIED UNSPECIFIED Haas, Matthias UNSPECIFIED UNSPECIFIED UNSPECIFIED Cash, Hannes UNSPECIFIED UNSPECIFIED UNSPECIFIED Miller, Kurt UNSPECIFIED UNSPECIFIED UNSPECIFIED Mahjoub, Samy UNSPECIFIED orcid.org/0000-0001-5151-1853 UNSPECIFIED Hartenstein, Alexander UNSPECIFIED UNSPECIFIED UNSPECIFIED Kaufmann, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Rotzinger, Roman UNSPECIFIED UNSPECIFIED UNSPECIFIED Lee, Chau Hung UNSPECIFIED UNSPECIFIED UNSPECIFIED Asbach, Patrick UNSPECIFIED UNSPECIFIED UNSPECIFIED Hamm, Bernd UNSPECIFIED UNSPECIFIED UNSPECIFIED Penzkofer, Tobias UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340229
DOI:	10.1007/s00330-020-06773-1
Journal or Publication Title:	Eur. Radiol.
Volume:	30
Number:	8
Page Range:	S. 4262 - 4272
Date:	2020
Publisher:	SPRINGER
Place of Publication:	NEW YORK
ISSN:	1432-1084
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language GUIDED TARGETED BIOPSY; TRANSITION-ZONE; DATA SYSTEM; DIFFERENTIATION; MRI; ULTRASONOGRAPHY; HYPERPLASIA; CRITERIA Multiple languages Radiology, Nuclear Medicine & Medical Imaging Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34022