Universität zu Köln

Wybranski, Christian, Siedek, Florian, Damm, Robert, Gazis, Angelos, Wenzel, Ortrud, Haneder, Stefan, Persigehl, Thorsten, Steinhauser, Susanne, Pech, Maciej, Fischbach, Frank and Fischbach, Katharina (2020). Respiratory motion artefacts in Gd-EOB-DTPA (Primovist/Eovist) and Gd-DOTA (Dotarem)-enhanced dynamic phase liver MRI after intensified and standard pre-scan patient preparation: A bi-institutional analysis. PLoS One, 15 (3). SAN FRANCISCO: PUBLIC LIBRARY SCIENCE. ISSN 1932-6203

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Abstract

Objective The objective of this study is to evaluate if intensified pre-scan patient preparation (IPPP) that comprises custom-made educational material on dynamic phase imaging and supervised pre-imaging breath-hold training in addition to standard informative conversation with verbal explanation of breath-hold commands (standard pre-scan patient preparationSPPP) might reduce the incidence of gadoxetate disodium (Gd-EOB-DTPA)-related transient severe respiratory motion (TSM) and severity of respiratory motion (RM) during dynamic phase liver MRI. Material and methods In this bi-institutional study 100 and 110 patients who received Gd-EOB-DTPA for dynamic phase liver MRI were allocated to either IPPP or SPPP at site A and B. The control group comprised 202 patients who received gadoterate meglumine (Gd-DOTA) of which each 101 patients were allocated to IPPP or SPPP at site B. RM artefacts were scored retrospectively in dynamic phase images (1: none-5: extensive) by five and two blinded readers at site A and B, respectively, and in the hepatobiliary phase of the Gd-EOB-DTPA-enhanced scans by two blinded readers at either site. Results The incidence of TSM was 15% at site A and 22.7% at site B (p = 0.157). IPPP did not reduce the incidence of TSM in comparison to SPPP: 16.7% vs. 21.6% (p = 0.366). This finding was consistent at site A: 12% vs. 18% (p = 0.401) and site B: 20.6% vs. 25% (p = 0.590). The TSM incidence in patients with IPPP and SPPP did not differ significantly between both sites (p = 0.227; p = 0.390). IPPP did not significantly mitigate RM in comparison to SPPP in any of the Gd-EOB-DTPA-enhanced dynamic phases and the hepatobiliary phase in patients without TSM (all p >= 0.072). In the Gd-DOTA control group on the other hand, IPPP significantly mitigated RM in all dynamic phases in comparison to SPPP (all p <= 0.031). Conclusions We conclude that Gd-EOB-DTPA-related TSM cannot be mitigated by education and training and that Gd-EOB-DTPA-related breath-hold difficulty does not only affect the subgroup of patients with TSM or exclusively the arterial phase as previously proposed.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Wybranski, Christian UNSPECIFIED UNSPECIFIED UNSPECIFIED Siedek, Florian UNSPECIFIED UNSPECIFIED UNSPECIFIED Damm, Robert UNSPECIFIED UNSPECIFIED UNSPECIFIED Gazis, Angelos UNSPECIFIED UNSPECIFIED UNSPECIFIED Wenzel, Ortrud UNSPECIFIED UNSPECIFIED UNSPECIFIED Haneder, Stefan UNSPECIFIED UNSPECIFIED UNSPECIFIED Persigehl, Thorsten UNSPECIFIED UNSPECIFIED UNSPECIFIED Steinhauser, Susanne UNSPECIFIED UNSPECIFIED UNSPECIFIED Pech, Maciej UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischbach, Frank UNSPECIFIED UNSPECIFIED UNSPECIFIED Fischbach, Katharina UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-340487
DOI:	10.1371/journal.pone.0230024
Journal or Publication Title:	PLoS One
Volume:	15
Number:	3
Date:	2020
Publisher:	PUBLIC LIBRARY SCIENCE
Place of Publication:	SAN FRANCISCO
ISSN:	1932-6203
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language HEPATIC ARTERIAL PHASE; TRANSIENT SEVERE MOTION; DISODIUM-ENHANCED MRI; BREATH-HOLD TECHNIQUE; GADOXETATE DISODIUM; REDUCING ARTIFACTS; PRIOR EPISODE; ACID; INFORMATION; ACQUISITION Multiple languages Multidisciplinary Sciences Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34048