Universität zu Köln

Sureda, Anna, Chabannon, Christian ORCID: 0000-0002-3755-4889, Masszi, Tamas, Pohlreich, David, Scheid, Christof, Thieblemont, Catherine ORCID: 0000-0002-9941-2448, Wahlin, Bjorn E., Sakellari, Ioanna, Russell, Nigel, Janikova, Andrea, Dabrowska-Iwanicka, Anna ORCID: 0000-0001-8986-0397, Touzeau, Cyrille ORCID: 0000-0003-0275-2575, Esquirol, Albert, Jantunen, Esa, van der Werf, Steffie, Bosman, Paul, Boumendil, Ariane ORCID: 0000-0002-2552-0542, Liu, Qianying, Celanovic, Marina, Montoto, Silvia and Dreger, Peter (2020). Analysis of data collected in the European Society for Blood and Marrow Transplantation (EBMT) Registry on a cohort of lymphoma patients receiving plerixafor. Bone Marrow Transplant., 55 (3). S. 613 - 623. LONDON: NATURE PUBLISHING GROUP. ISSN 1476-5365

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Abstract

Plerixafor + granulocyte-colony stimulating factor (G-CSF) is administered to patients with lymphoma who are poor mobilizers of hematopoietic stem cells (HSCs) in Europe. This international, multicenter, non-interventional registry study (NCT01362972) evaluated long-term follow-up of patients with lymphoma who received plerixafor for HSC mobilization versus other mobilization methods. Propensity score matching was conducted to balance baseline characteristics between comparison groups. The following mobilization regimens were compared: G-CSF + plerixafor (G + P) versus G-CSF alone; G + P versus G-CSF + chemotherapy (G + C); and G-CSF + plerixafor + chemotherapy (G + P + C) versus G + C. The primary outcomes were progression-free survival (PFS), overall survival (OS), and cumulative incidence of relapse (CIR). Overall, 313/3749 (8.3%) eligible patients were mobilized with plerixafor-containing regimens. After propensity score matching, 70 versus 36 patients were matched in the G + P versus G-CSF alone cohort, 124 versus 124 in the G + P versus G + C cohort, and 130 versus 130 in the G + P + C versus G + C cohort. For both PFS and OS, the upper bound of confidence interval for the hazard ratio was >1.3 for all comparisons, implying that non-inferiority was not demonstrated. No major differences in PFS, OS, and CIR were observed between the plerixafor and comparison groups.

Item Type:	Journal Article
Creators:	Creators Email ORCID ORCID Put Code Sureda, Anna UNSPECIFIED UNSPECIFIED UNSPECIFIED Chabannon, Christian UNSPECIFIED orcid.org/0000-0002-3755-4889 UNSPECIFIED Masszi, Tamas UNSPECIFIED UNSPECIFIED UNSPECIFIED Pohlreich, David UNSPECIFIED UNSPECIFIED UNSPECIFIED Scheid, Christof UNSPECIFIED UNSPECIFIED UNSPECIFIED Thieblemont, Catherine UNSPECIFIED orcid.org/0000-0002-9941-2448 UNSPECIFIED Wahlin, Bjorn E. UNSPECIFIED UNSPECIFIED UNSPECIFIED Sakellari, Ioanna UNSPECIFIED UNSPECIFIED UNSPECIFIED Russell, Nigel UNSPECIFIED UNSPECIFIED UNSPECIFIED Janikova, Andrea UNSPECIFIED UNSPECIFIED UNSPECIFIED Dabrowska-Iwanicka, Anna UNSPECIFIED orcid.org/0000-0001-8986-0397 UNSPECIFIED Touzeau, Cyrille UNSPECIFIED orcid.org/0000-0003-0275-2575 UNSPECIFIED Esquirol, Albert UNSPECIFIED UNSPECIFIED UNSPECIFIED Jantunen, Esa UNSPECIFIED UNSPECIFIED UNSPECIFIED van der Werf, Steffie UNSPECIFIED UNSPECIFIED UNSPECIFIED Bosman, Paul UNSPECIFIED UNSPECIFIED UNSPECIFIED Boumendil, Ariane UNSPECIFIED orcid.org/0000-0002-2552-0542 UNSPECIFIED Liu, Qianying UNSPECIFIED UNSPECIFIED UNSPECIFIED Celanovic, Marina UNSPECIFIED UNSPECIFIED UNSPECIFIED Montoto, Silvia UNSPECIFIED UNSPECIFIED UNSPECIFIED Dreger, Peter UNSPECIFIED UNSPECIFIED UNSPECIFIED
URN:	urn:nbn:de:hbz:38-342863
DOI:	10.1038/s41409-019-0693-z
Journal or Publication Title:	Bone Marrow Transplant.
Volume:	55
Number:	3
Page Range:	S. 613 - 623
Date:	2020
Publisher:	NATURE PUBLISHING GROUP
Place of Publication:	LONDON
ISSN:	1476-5365
Language:	English
Faculty:	Unspecified
Divisions:	Unspecified
Subjects:	no entry
Uncontrolled Keywords:	Keywords Language STEM-CELL MOBILIZATION; MULTIPLE-MYELOMA; CHEMOKINE RECEPTOR; POOR MOBILIZATION; AMD3100 Multiple languages Biophysics; Oncology; Hematology; Immunology; Transplantation Multiple languages
URI:	http://kups.ub.uni-koeln.de/id/eprint/34286